Neurochemical Research

, Volume 33, Issue 3, pp 589–597 | Cite as

Mitochondrial Dysfunction and Oxidative Stress in Parkinson’s Disease

Original Paper


Environmental toxins, genetic predisposition and old age are major risk factors for Parkinson’s disease (PD). Although the mechanism(s) underlying selective dopaminergic (DA) neurodegeneration remain unclear, molecular studies in both toxin based models and genetic based models of the disease suggest a major etiologic role for mitochondrial dysfunction in the pathogenesis of PD. Further, recent studies have presented clear evidence for a high burden of mtDNA deletions within the substantia nigra neurons in individuals with PD. Ultimately, an understanding of the molecular events which precipitate DA neurodegeneration in idiopathic PD will enable the development of targeted and effective therapeutic strategies. We review recent advances and current understanding of the genetic factors, molecular mechanisms and animal models of PD.


Parkinson’s disease Mitochondrial dysfunction Oxidative stress mtDNA Environmental toxins Neurodegeneration Lewy bodies Proteasome Rotenone MPTP Cybrids 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Center for the Study of Neurodegenerative DiseasesUniversity of Virginia School of MedicineCharlottesvilleUSA
  2. 2.Department of NeurologyUniversity of Virginia School of MedicineCharlottesvilleUSA
  3. 3.Department of NeuroscienceUniversity of Virginia School of MedicineCharlottesvilleUSA
  4. 4.University of VirginiaCharlottesvilleUSA

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