Neurochemical Research

, Volume 32, Issue 11, pp 1950–1956 | Cite as

Naturally Occurring Compounds Affect Glutamatergic Neurotransmission in Rat Brain

  • Lucia Helena Martini
  • Fernanda Jung
  • Felix Antunes Soares
  • Liane Nanci Rotta
  • Deusa Aparecida Vendite
  • Marcos Emilio dos Santos Frizzo
  • Rosendo A. Yunes
  • João Batista Calixto
  • Susana Wofchuk
  • Diogo O. Souza
Original Paper


Natural products, including those derived from plants, have largely contributed to the development of therapeutic drugs. Glutamate is the main excitatory neurotransmitter in the central nervous system and it is also considered a nociceptive neurotransmitter, by acting on peripheral nervous system. For this reason, in this study we investigated the effects of the hydroalcooholic extracts from Drymis winteri (polygodial and drimanial), Phyllanthus (rutin and quercetine), Jathopha elliptica (jatrophone), Hedyosmum brasiliense (13HDS), Ocotea suaveolens (Tormentic acid), Protium kleinii (αβ-amyrin), Citrus paradise (naringin), soybean (genistein) and Crataeva nurvala (lupeol), described as having antinociceptive effects, on glutamatergic transmission parameters, such as [3H]glutamate binding, [3H]glutamate uptake by synaptic vesicles and astrocyte cultures, and synaptosomal [3H]glutamate release. All the glutamatergic parameters were affected by one or more of these compounds. Specifically, drimanial and polygodial presented more broad and profound effects, requiring more investigation on their mechanisms. The putative central side effects of these compounds, via the glutamatergic system, are discussed.


Glutamate transmision Antinociception Naturally occurring compounds CNS Side effects 



This work was supported by FAPERGS and CNPq.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Lucia Helena Martini
    • 1
  • Fernanda Jung
    • 1
  • Felix Antunes Soares
    • 1
  • Liane Nanci Rotta
    • 2
    • 3
  • Deusa Aparecida Vendite
    • 1
  • Marcos Emilio dos Santos Frizzo
    • 4
  • Rosendo A. Yunes
    • 5
  • João Batista Calixto
    • 6
  • Susana Wofchuk
    • 1
  • Diogo O. Souza
    • 1
  1. 1.Departamento de Bioquímica, Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Fundação Faculdade Federal de Ciências Médicas de Porto AlegrePorto AlegreBrazil
  3. 3.Universidade Luterana do BrasilCanoasBrazil
  4. 4.Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  5. 5.Departamento de QuímicaUniversidade Federal Santa CatarinaFlorianopolisBrazil
  6. 6.Departamento de FarmacologiaUniversidade Federal de Santa Catarina, CCBFlorianopolisBrazil

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