Neurochemical Research

, Volume 32, Issue 4–5, pp 807–821 | Cite as

Randomized Clinical Stroke Rehabilitation Trials in 2005

  • Meheroz H. Rabadi
Original Paper


This article reviews randomized control trials (RCTs) undertaken in stroke rehabilitation in the year 2005. A Medline search generated 31 RCTs in stroke rehabilitation in the year 2005 in the English language. These trials were primarily efficacy studies of a number of treatments: medications such as folate, vitamin B12 and bisphosphonates in preventing osteoporotic related hip fractures, compression stockings in preventing deep vein thrombosis (DVT), use of mechanical robots and positioning of the upper limb to help improve function; and, transcranial magnetic coil stimulation, acupuncture and neural tissue transplant to enhance motor recovery in post-stroke patients.


Randomized control trials Stroke rehabilitation 


  1. 1.
    Mayo NE, Wood-Dauphinee S, Cote R, Gayton D, Carlton J, Buttery J, Tamblyn R (2000) There’s no place like home: an evaluation of early supported discharge for stroke. Stroke 31(5):1016–1023PubMedGoogle Scholar
  2. 2.
    Thorsen AM, Holmqvist LW, de Pedro-Cuesta J, von Koch L (2005) A randomized controlled trial of early supported discharge and continued rehabilitation at home after stroke: five-year follow-up of patient outcome. Stroke 36(2):297–303PubMedCrossRefGoogle Scholar
  3. 3.
    Fjaertoft H, Indredavik B, Magnussen J, Johnsen R (2005) Early supported discharge for stroke patients improves clinical outcome. Does it also reduce use of health services and costs? One-year follow-up of a randomized controlled trial. Cerebrovasc Dis 19(6):376–383PubMedCrossRefGoogle Scholar
  4. 4.
    Grasel E, Biehler J, Schmidt R, Schupp W (2005) Intensification of the transition between inpatient neurological rehabilitation and home care of stroke patients. Controlled clinical trial with follow-up assessment six months after discharge. Clin Rehabil 19(7):725–736PubMedCrossRefGoogle Scholar
  5. 5.
    Dey P, Woodman M, Gibbs A, Steele R, Stocks SJ, Wagstaff S, Khanna V, Chaudhuri MD (2005) Early assessment by a mobile stroke team: a randomised controlled trial. Age Ageing 34(4):331–338PubMedCrossRefGoogle Scholar
  6. 6.
    Kondziolka D, Steinberg GK, Wechsler L, Meltzer CC, Elder E, Gebel J, Decesare S, Jovin T, Zafonte R, Lebowitz J, Flickinger JC, Tong D, Marks MP, Jamieson C, Luu D, Bell-Stephens T, Teraoka J (2005) Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg 103(1):38–45PubMedCrossRefGoogle Scholar
  7. 7.
    Khedr EM, Ahmed MA, Fathy N, Rothwell JC (2005) Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke. Neurology 65:466–468PubMedCrossRefGoogle Scholar
  8. 8.
    Takeuchi N, Chuma T, Matsuo Y, Watanabe I, Ikoma K (2005) Repetitive transcranial magnetic stimulation of contralesional primary motor cortex improves hand function after stroke. Stroke 36(12):2681–2686PubMedCrossRefGoogle Scholar
  9. 9.
    Mansur CG, Fregni F, Boggio PS, Riberto M, Gallucci-Neto J, Santos CM, Wagner T, Rigonatti SP, Marcolin MA, Pascual-Leone A (2005) A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients. Neurology 64(10):1802–1804PubMedCrossRefGoogle Scholar
  10. 10.
    Sze FK, Wong E, Or KK, Lau J, Woo J (2002) Does acupuncture improve motor recovery after stroke? A meta-analysis of randomized controlled trials. Stroke 33(11):2604–2619PubMedCrossRefGoogle Scholar
  11. 11.
    Wu H, Tang J, Lin X, Lau J, Leung P, Woo J, Li Y (2006) Acupuncture for stroke rehabilitation. Cochrane Database Syst Rev 3:CD004131Google Scholar
  12. 12.
    Park J, White AR, James MA, Hemsley AG, Johnson P, Chambers J, Ernst E (2005) Acupuncture for subacute stroke rehabilitation: a Sham-controlled, subject- and assessor-blind, randomized trial. Arch Intern Med 165(17):2026–2031PubMedCrossRefGoogle Scholar
  13. 13.
    Wayne PM, Krebs DE, Macklin EA, Schnyer R, Kaptchuk TJ, Parker SW, Scarborough DM, McGibbon CA, Schaechter JD, Stein J, Stason WB (2005) Acupuncture for upper-extremity rehabilitation in chronic stroke: a randomized sham-controlled study. Arch Phys Med Rehabil 86(12):2248–2255PubMedCrossRefGoogle Scholar
  14. 14.
    van der Lee JH, Snels IA, Beckerman H, Lankhorst GJ, Wagenaar RC, Bouter LM (2001) Exercise therapy for arm function in stroke patients: a systematic review of randomized controlled trials. Clin Rehabil 15(1):20–31PubMedCrossRefGoogle Scholar
  15. 15.
    Hesse S, Werner C, Pohl M, Rueckriem S, Mehrholz J, Lingnau ML (2005) Computerized arm training improves the motor control of the severely affected arm after stroke: a single-blinded randomized trial in two centers. Stroke 36(9):1960–1966PubMedCrossRefGoogle Scholar
  16. 16.
    Chen JC, Liang CC, Shaw FZ (2005) Facilitation of sensory and motor recovery by thermal intervention for the hemiplegic upper limb in acute stroke patients: a single-blind randomized clinical trial. Stroke 36(12):2665–2669PubMedCrossRefGoogle Scholar
  17. 17.
    Ada L, Goddard E, McCully J, Stavrinos T, Bampton J (2005) Thirty minutes of positioning reduces the development of shoulder external rotation contracture after stroke: a randomized controlled trial. Arch Phys Med Rehabil 86(2):230–234PubMedCrossRefGoogle Scholar
  18. 18.
    Jones A, Tilling K, Wilson-Barnett J, Newham DJ, Wolfe CD (2005) Effect of recommended positioning on stroke outcome at six months: a randomized controlled trial. Clin Rehabil 19(2):138–145PubMedCrossRefGoogle Scholar
  19. 19.
    Desrosiers J, Bourbonnais D, Corriveau H, Gosselin S, Bravo G (2005) Effectiveness of unilateral and symmetrical bilateral task training for arm during the subacute phase after stroke: a randomized controlled trial. Clin Rehabil 19(6):581–593PubMedCrossRefGoogle Scholar
  20. 20.
    Turton AJ, Britton E (2005) A pilot randomized controlled trial of a daily muscle stretch regime to prevent contractures in the arm after stroke. Clin Rehabil 19(6):600–612PubMedCrossRefGoogle Scholar
  21. 21.
    Platz T, Eickhof C, van Kaick S, Engel U, Pinkowski C, Kalok S, Pause M (2005) Impairment-oriented training or Bobath therapy for severe arm paresis after stroke: a single-blind, multicentre randomized controlled trial. Clin Rehabil 19(7):714–724PubMedCrossRefGoogle Scholar
  22. 22.
    Chae J, Yu DT, Walker ME, Kirsteins A, Elovic EP, Flanagan SR, Harvey RL, Zorowitz RD, Frost FS, Grill JH, Fang ZP (2005) Intramuscular electrical stimulation for hemiplegic shoulder pain: a 12-month follow-up of a multiple-center, randomized clinical trial. Am J Phys Med Rehabil 84(11):832–842PubMedCrossRefGoogle Scholar
  23. 23.
    Salbach NM, Mayo NE, Robichaud-Ekstrand S, Hanley JA, Richards CL, Wood-Dauphinee S (2005) The effect of a task-oriented walking intervention on improving balance self-efficacy poststroke: a randomized, controlled trial. J Am Geriatr Soc 53(4):576–582PubMedCrossRefGoogle Scholar
  24. 24.
    You SH, Jang SH, Kim YH, Hallett M, Ahn SH, Kwon YH, Kim JH, Lee MY (2005) Virtual reality-induced cortical reorganization and associated locomotor recovery in chronic stroke: an experimenter-blind randomized study. Stroke 36(6):1166–1171PubMedCrossRefGoogle Scholar
  25. 25.
    Yang YR, Yen JG, Wang RY, Yen LL, Lieu FK (2005) Gait outcomes after additional backward walking training in patients with stroke: a randomized controlled trial. Clin Rehabil 19(3):264–273PubMedCrossRefGoogle Scholar
  26. 26.
    Bagley P, Hudson M, Forster A, Smith J, Young J (2005) A randomized trial evaluation of the Oswestry Standing Frame for patients after stroke. Clin Rehabil 19(4):354–364PubMedCrossRefGoogle Scholar
  27. 27.
    Ramnemark A, Nilsson M, Borssen B, Gustafson Y (2000) Stroke, a major and increasing risk factor for femoral neck fracture. Stroke 31:1572–1577PubMedGoogle Scholar
  28. 28.
    Ramnemark A, Nyberg L, Borssen B, Olsson T, Gustafson Y (1998) Fractures after stroke. Osteoporos Int 8:92–95PubMedCrossRefGoogle Scholar
  29. 29.
    Mulley G, Espley AJ (1979) Hip fracture after hemiplegia. Postgrad Med J 55(642):264–265PubMedCrossRefGoogle Scholar
  30. 30.
    Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 293(9):1082–1088PubMedCrossRefGoogle Scholar
  31. 31.
    Sato Y, Iwamoto J, Kanoko T, Satoh K (2005) Risedronate therapy for prevention of hip fracture after stroke in elderly women. Neurology 64(5):811–816PubMedGoogle Scholar
  32. 32.
    Sato Y, Iwamoto J, Kanoko T, Satoh K (2005) Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis 20(3):187–192Google Scholar
  33. 33.
    Studenski S, Duncan PW, Perera S, Reker D, Lai SM, Richards L (2005) Daily functioning and quality of life in a randomized controlled trial of therapeutic exercise for subacute stroke survivors. Stroke 36(8):1764–1770PubMedCrossRefGoogle Scholar
  34. 34.
    Macko RF, Ivey FM, Forrester LW, Hanley D, Sorkin JD, Katzel LI, Silver KH, Goldberg AP (2005) Treadmill exercise rehabilitation improves ambulatory function and cardiovascular fitness in patients with chronic stroke: a randomized, controlled trial. Stroke 36(10):2206–2211PubMedCrossRefGoogle Scholar
  35. 35.
    Pang MY, Eng JJ, Dawson AS, McKay HA, Harris JE (2005) A community-based fitness and mobility exercise program for older adults with chronic stroke: a randomized, controlled trial. J Am Geriatr Soc 53(10):1667–1674PubMedCrossRefGoogle Scholar
  36. 36.
    Akinwuntan AE, De Weerdt W, Feys H, Pauwels J, Baten G, Arno P, Kiekens C (2005) Effect of simulator training on driving after stroke: a randomized controlled trial. Neurology 65(6):843–850PubMedCrossRefGoogle Scholar
  37. 37.
    Lacut K, Bressollette L, Le Gal G, Etienne E, De Tinteniac A, Renault A, Rouhart F, Besson G, Garcia JF, Mottier D, Oger E (2005) VICTORIAh (Venous Intermittent Compression and Thrombosis Occurrence Related to Intra-cerebral Acute hemorrhage) Investigators. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology 65(6):865–869PubMedCrossRefGoogle Scholar
  38. 38.
    Pennington L, Roddam H, Burton C, Russell I, Godfrey C, Russell D (2005) Promoting research use in speech and language therapy: a cluster randomized controlled trial to compare the clinical effectiveness and costs of two training strategies. Clin Rehabil 19(4):387–397PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  1. 1.Burke Rehabilitation HospitalWeill Medical College of Cornell UniversityWhite PlainsUSA

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