Neurochemical Research

, Volume 32, Issue 4–5, pp 695–706 | Cite as

Alzheimer Disease—No Target for Statin Treatment. A Mini Review

  • Siegfried Hoyer
  • Peter Riederer
Review Article


Nosologically, Alzheimer disease (AD) is not a single disorder. A minority of around 400 families worldwide can be grouped as hereditary in origin, whereas the majority of all Alzheimer cases (approx. 25 million worldwide) are sporadic in origin. In the pathophysiology of the latter type, a number of susceptibility genes contribute to the disease among which are allelic abnormalities of the apolipoprotein E4 gene pointing to a link between disturbed cholesterol metabolism and sporadic AD. Cholesterol is a main component of membrane composition enriched in microdomains and is functionally linked to the proteolytic processing of amyloid precursor protein (APP). In sporadic AD, a marked diminution of both membrane phospholipids and cholesterol has been found. Evidence has been provided that high plasma cholesterol may protect from AD. In contrast to these well documented abnormalities observed in AD patients, it was assumed that an elevated cholesterol concentration might favour the generation of β-amyloid and, thus, AD. However, a series of in vitro-and in vivo-studies did not provide evidence for the assumption that an enhanced cholesterol concentration increased βA4-production. A harsh reduction of membrane cholesterol only caused a “beneficial” effect of APP metabolism. However, this experimentally induced condition may not be compatible to sporadic AD. The application of statins in sporadic AD did not yield results to assume that this therapeutic strategy may prevent or treat successfully sporadic AD.


Alzheimer disease Membrane Cholesterol Statins Amyloid 


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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  1. 1.Department of PathologyUniversity of HeidelbergHeidelbergGermany
  2. 2.Department of Clinical Neurochemistry, Psychiatric ClinicUniversity of WürzburgWürzburgGermany

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