Neurochemical Research

, Volume 30, Issue 10, pp 1283–1288 | Cite as

Carnosine Protects the Brain of Rats and Mongolian Gerbils against Ischemic Injury: After-Stroke-Effect

  • Dusan Dobrota
  • Tatiana Fedorova
  • Sergey Stvolinsky
  • Eva Babusikova
  • Katarina Likavcanova
  • Anna Drgova
  • Adriana Strapkova
  • Alexander Boldyrev


Carnosine, a specific constituent of excitable tissues of vertebrates, exhibits a significant antioxidant protecting effect on the brain damaged by ischemic-reperfusion injury when it was administered to the animals before ischemic episode. In this study, the therapeutic effect of carnosine was estimated on animals when this drug was administered intraperitoneally (100 mg/kg body weight) after ischemic episode induced by experimental global brain ischemia. Treatment of the animals with carnosine after ischemic episode under long-term (7–14 days) reperfusion demonstrated its pronounced protective effect on neurological symptoms and animal mortality. Carnosine also prevented higher lipid peroxidation of brain membrane structures and increased a resistance of neuronal membranes to the in vitro induced oxidation. Measurements of malonyl dialdehyde (MDA) in brain homogenates showed its increase in the after brain stroke animals and decreased MDA level in the after brain stroke animals treated with carnosine. We concluded that carnosine compensates deficit in antioxidant defense system of brain damaged by ischemic injury. The data presented demonstrate that carnosine is effective in protecting the brain in the post-ischemic period.

Key words

Brain ischemia oxidative stress antioxidant activity carnosine Mongolian gerbils rats 


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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Dusan Dobrota
    • 1
    • 4
  • Tatiana Fedorova
    • 2
  • Sergey Stvolinsky
    • 2
  • Eva Babusikova
    • 1
  • Katarina Likavcanova
    • 1
  • Anna Drgova
    • 1
  • Adriana Strapkova
    • 1
  • Alexander Boldyrev
    • 2
    • 3
  1. 1.Department of Medical BiochemistryJessenius Faculty of Medicine, Comenius UniversityMartinSlovakia
  2. 2.Laboratory of NeurochemistryInstitute of Neurology, Russian Academy of Medical SciencesMoscowRussia
  3. 3.Department of BiochemistryInternational Biotechnological Center of M.V. Lomonosov Moscow State UniversityMoscowRussia
  4. 4.Department of Medical BiochemistryJessenius Faculty of Medicine, Comenius UniversityMartinSlovakia

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