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Neurochemical Research

, Volume 30, Issue 9, pp 1171–1177 | Cite as

Aging-related Correlation of Insulin-degrading Enzyme with γ-Secretase-generated Products Involving Insulin and Glucose Levels in Transgenic Mice

  • Dae Y. Hwang
  • Jung S. Cho
  • Chuel K. Kim
  • Sun B. Shim
  • Seung W. Jee
  • Su H. Lee
  • Su J. Seo
  • Joon Y. Cho
  • Seok H. Lee
  • Yong K. Kim
Article

Abstract

Insulin-degrading enzyme (IDE) is a 110-kDa thiol zinc-methalloendopeptidase that can cleave small Aβ peptides and the APP intracellular domain (AICD). The aim of this study was to examine aging-related correlation of IDE with γ-secretase-generated products involving insulin and glucose levels in transgenic brains expressing neuron-specific enolase (NSE)-controlled human mutant presenilin-2 (hPS2m). Herein, we concluded that the levels of IDE expression in transgenic brains were decreased relative to those of control mice at 15 months of age. In parallel, inhibition in the IDE expression at this age underlies to the levels-up of Aβ-42, AICD, γ-secretase, and glucose with a level-down of insulin. Thus, IDE expression is critical target for the therapeutic trials.

Keywords

γ-secretase Aβ AICD Alzheimer glucose IDE insulin transgenic 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Dae Y. Hwang
    • 1
  • Jung S. Cho
    • 1
  • Chuel K. Kim
    • 1
  • Sun B. Shim
    • 1
  • Seung W. Jee
    • 1
  • Su H. Lee
    • 1
  • Su J. Seo
    • 1
  • Joon Y. Cho
    • 2
  • Seok H. Lee
    • 3
  • Yong K. Kim
    • 1
  1. 1.Division of Laboratory Animal Resources, National Institute of Toxicological ResearchSeoulKorea
  2. 2.Exercise Biochemistry LaboratoryKorea National Sport UniversityKorea
  3. 3.National Institute of Toxicological ResearchSeoulKorea

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