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Neurochemical Research

, Volume 30, Issue 3, pp 311–314 | Cite as

Nitrite/Nitrate (NO x ) and Zinc Concentrations in Influenza-associated Encephalopathy in Children with Different Sequela

  • Hisashi Kawashima
  • Masahiro Amaha
  • Hiroaki Ioi
  • Gaku Yamanaka
  • Yasuyo Kashiwagi
  • Masato Sasamoto
  • Kouji Takekuma
  • Akinori Hoshika
  • Yasuo Watanabe
Article

Abstract

NOx (NO2 and NO3) in CSF obtained from 22 patients with influenza-associated encephalopathy were higher than those of a control group. Within the different prognosis, there were no significant differences in NOx levels. By analyzing the serum obtained from patients infected with influenza, including encephalopathy, with others, the serum zinc levels did show marked differences between them. Four out of eleven patients with influenza-associated encephalopathy showed low zinc levels below the normal range. However, there were no significant differences in the zinc levels between the group with sequela and without sequela. These results indicate that the increase of NOx levels detected in influenza-associated encephalopathy relates to the low zinc levels, and both low molecules might play an important role for the cause of encephalopathy.

Keywords

Influenza-associated encephalopathy zinc NOx children seizure 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Hisashi Kawashima
    • 1
    • 3
  • Masahiro Amaha
    • 1
  • Hiroaki Ioi
    • 1
  • Gaku Yamanaka
    • 1
  • Yasuyo Kashiwagi
    • 1
  • Masato Sasamoto
    • 1
  • Kouji Takekuma
    • 1
  • Akinori Hoshika
    • 1
  • Yasuo Watanabe
    • 2
  1. 1.Department of PaediatricsTokyo Medical UniversityJapan
  2. 2.Department of PharmacologyTokyo Medical UniversityJapan
  3. 3.Department of PaediatricsTokyo Medical UniversityTokyoJapan

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