Neurochemical Research

, Volume 29, Issue 12, pp 2287–2292 | Cite as

Caffeic Acid Phenethyl Ester Exerts a Neuroprotective Effect on CNS Against Pentylenetetrazol-Induced Seizures in Mice

  • Atilla Ilhan
  • Mustafa Iraz
  • Ahmet Gurel
  • Ferah Armutcu
  • Omer Akyol


Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.


Caffeic acid phenethyl ester seizure oxidative damage brain 


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Copyright information

© Springer Science+Business Media, Inc. 2004

Authors and Affiliations

  • Atilla Ilhan
    • 1
    • 5
  • Mustafa Iraz
    • 2
  • Ahmet Gurel
    • 3
  • Ferah Armutcu
    • 4
  • Omer Akyol
    • 5
  1. 1.Departments of Neurology, Medical FacultyInonu UniversityMalatyaTurkey
  2. 2.Medical Faculty, Departments of PharmacologyInonu UniversityMalatyaTurkey
  3. 3.Medical Faculty, Department of BiochemistryKaraelmas University ZonguldakTurkey
  4. 4.Medical Faculty, Departments of BiochemistryInonu UniversityMalatyaTurkey
  5. 5.Medical Faculty, Department of Neurology, Turgut Ozal Medical CenterInonu UniversityMalatyaTurkey

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