Effects of course (5 days) peroral introductions of memantine on behavioral indices of rafts in the open field test were examined. Ten animals were divided into two groups, control and experimental; rats of the latter group obtained five everyday introductions of 20 mg/kg memantine hydrochloride. Animals of the experimental group demonstrated more intense orientational/research activity (number of rearings) and significantly greater number of goings to the arena center. The dynamics of nearly all indices shown by rats of the two groups were dissimilar; memantine noticeably modified the structure of grooming behavior. Behavioral patterns in the open field allow one to conclude that memantine induces significant decreases in the levels of anxiety and fear. In general, effects of this agent can be characterized as adaptational/stimulatory ones. [1, 2]
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Tyshchenko, Y.M., Lukyanetz, E.A. Effects of Memantine on Behavioral Indices of Rats in the Open Field. Neurophysiology 49, 453–457 (2017). https://doi.org/10.1007/s11062-018-9708-4
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DOI: https://doi.org/10.1007/s11062-018-9708-4