Effects of Bacterial Melanin on Neuronal Activity in the Rat Sensorimotor Cortex
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We examined post-stimulation changes in the electrical activity of neurons of the rat sensorimotor cortex after intapraperitoneal injections or direct applications of bacterial melanin (a strict analog of neuromelanin). Activation of cortical neurons was evoked by high-frequency stimulation of the hindlimb peripheral nerves. The patterns of within-stimulation responses and long-lasting post-stimulation effects were rather similar in both subgroups (with systemic introductions or direct applications of melanin). Comparison of the results of previous electrophysiological experiments, where the effects of melanin on electrical activity generated by neurons of the substantia nigra pars compacta were studied, showed close similarities of the effects of this agent (mostly activating influence of bacterial melanin with the predominance of excitatory/facilitatory post-stimulation modifications of spike activity). The effects of bacterial melanin can contribute to the recovery processes in neurodegenerative diseases.
Keywordsmelanin neurons of the sensorimotor cortex evoked spike activity potentiation depression
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- 7.T. R Petrosyan, V. A. Chavushyan, and A. S. Hovsepyan, “Bacterial melanin increases electrical activity of neurons in substantia nigra pars compacta,” J. Neur. Transmiss., 121, 259-265 (2014).Google Scholar
- 10.D. L. Berliner, R. L. Erwin, and D. R. McGee, “Methods of treating Parkinson’s disease using melanin,” US Patent 5,210,076 A (1993).Google Scholar
- 11.T. R. Petrosyan and A. S. Hovsepyan, “Bacterial melanin crosses the blood–brain barrier in rat experimental model,” Fluids Barriers CNS, 11, No. 20, 1-7 (2014).Google Scholar
- 14.O.V. Gevorkyan, “Neuronal activity of sensorimotor cortex on the mesencephalic reticular formation stimulation,” Biol. J. Armenia, 40, No. 12, 993-997 (1987).Google Scholar
- 17.A. A. Galoyan, J. S. Sarkissian, T. K. Kipriyan, et al., “Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus,” J. Physiol., 15, No. 533, 237-252 (2001).Google Scholar