Spike Timing-Dependent Plasticity in the CA1 Pyramidal Neuron in a Modeled Hippocampal Circuit
- 67 Downloads
Spike timing-dependent plasticity (STDP) plays an important role in sculpting information-storing circuits in the hippocampus, since motor learning and memory are thought to be closely linked with this classical plasticity. To further understand the information delivery in a hippocampus circuit, we build a computational model to study the potential role of linear changes in the synaptic weight and synaptic number. Several key results have been obtained: (i) Changes in the synaptic weight and numbers lead to different long-term modifications; (ii) the first paired spiking from two neurons significantly influences the adjusted subsequent paired spiking; the pre-post spiking pair strengthens the following paired spiking; however, the post-pre spiking pair depresses the subsequent spiking; (iii) when the synaptic weight and synaptic numbers are changed, the interval of the first spiking pair may undergo reduction, and (iv) when we stimulate a stellate neuron weakly or decrease the capacitance of the CA1 pyramidal neuron, LTP is more easily produced than LTD; on the contrary, LTD is more easily produced in an opposite situation; increase in the synaptic numbers can promote activation of the CA1 pyramidal neuron.
Keywordscomputational model hippocampus neuronal circuits spike timing-dependent synaptic plasticity (STDP) synaptic weight and number
Unable to display preview. Download preview PDF.
- 2.R. C. Malenka and S. A. Siegelbaum, Synaptic Plasticity, Johns Hopkins Univ. Press (2001).Google Scholar
- 8.C. Vassilis, C. Stuart, and P. G. Bruce, “Encoding and retrieval in a model of the hippocampal CA1 microcircuit,” Hippocampus, 20, 423-446 (2010).Google Scholar
- 11.W. M. Yamada, C. Koch, and P. R. Adams, Multiple Channels and Calcium Dynamics, MIT Press, Cambridge (1987).Google Scholar
- 13.R. Michel, M. T. Horstmann, R. Stefan, et al., “Role of axonal Na V 1.6 sodium channels in action potential initiation of CA1 pyramidal neurons,” J. Physiol., 4, 2361-2380 (2008).Google Scholar