Two Types of Epileptiform Activity Induced in Rats by Repeated Injections of Subconvulsive Picrotoxin Doses
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Seizure activity in rats was induced by picrotoxin i.p. injected every 30 min for 4 h in subconvulsive doses (0.9 mg/kg in the first and 0.7 mg/kg in subsequent injections). Such picrotoxin-evoked epileptiform activity (EA) could be divided into two types, with the development of exclusively peak-wave (P-W) complexes (68.4%) and with generation of regular cortical peaks and only separate short P-W discharges (31.6%). In animals with EA of the first type, we observed the gradual development of clonic seizures of increasing intensities. In some rats of this group after the final (ninth) injection of picrotoxin, dramatic clonico-tonic seizures were observed. In animals with EA of the second type, the duration of P-W discharges after final injections of picrotoxin was shorter than in rats without generation of cortical peaks; these discharges were accompanied by clonic seizures of smaller intensity.
Keywordsepileptiform activity picrotoxin seizures peak-wave EEG discharges regular cortical peak discharges
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- 1.A. S. Galanopoulou and S. L. Moshé, “The epileptic hypothesis: developmentally related arguments based on animal models,” Epilepsia, 50, Suppl. 7, 37-42 (2009).Google Scholar
- 2.E. J. Frances, “Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience,” Epilepsia, 52, Suppl. 1, 1-6 (2011).Google Scholar
- 4.E. W. Lothman, J. M. Hatelid, C. F. Zorumski, et al., “Kindling with rapidly recurring hippocampal seizures,” Brain Res., 360, Nos. 1/2, 83-91 (1985).Google Scholar
- 5.A. A. Shandra, L. S. Godlevskii, and A. I. Brusentsov, Kindling and Epileptic Activity [in Russian], Astroprint, Odessa (1999).Google Scholar
- 7.L. Kruger, S. Saporta, and W. Larry, Photographic Atlas of the Rat Brain, the Cell and Fiber Architecture Illustrated in Three Planes with Stereotaxic Coordinates, Cambridge Univ. Press, Cambridge (1995).Google Scholar
- 8.A. A. Shandra, Principles of and Techniques for Pathogenetic Therapy of Epilepsy [in Russian], Abstr. of Doctoral Thesis, Med. Sci., Moscow(1985).Google Scholar
- 9.M. Barbarosie, J. Louve, M. D’Antuono, et al., «Masking of synchronous GABA-mediated potentials controls limbic seizures,»Epilepsia, 43, No. 12, 1469- 1479 (2002).Google Scholar
- 13.O. V. Denisenko, T. V. Buzyka, O. A. Kashchenko, and O. A. Shandra, “Analysis of interictal spike activity in the hippocampus and neocortex at the development of pentylenetetrazole kindling in rats,” Dosyagn. Biol. Med., No. 3, 32-36 (2007).Google Scholar