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Neurophysiology

, Volume 46, Issue 4, pp 381–383 | Cite as

Effects of Electrical Stimulation of the Cerebellum and Injections of Levetiracetam on Aggressive Behavior of Kindling Rats

  • T. M. Muratova
  • V. V. Godovan
  • L. S. Godlevsky
  • E. V. Kobolev
Article

In rats with the corazole-induced kindling syndrome, we estimated the conditions for the appearance of battles on an electrified floor; the threshold for initiation of aggressive reactions in kindling animals was lower, on average, by 41.5%, as compared with the corresponding index in intact animals. Combination of electrical stimulation (ES) of the paleocerebellar cortex (lobules V-VII; 100 sec–1; altogether 10 sessions of ES) and injection of levetiracetam (40.0 mg/kg, i.p.), which per se did not influence significantly aggressive behavior of kindling rats, led to an increase in the threshold for the appearance of battles, on average, by 28.8% (P < 0.05), compared with the initial value in the tested animals, i.e., to a drop in the level of aggressiveness.

Keywords

chemical kindling aggressive behavior electrical stimulation (ES) of the cerebellum levetiracetam 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • T. M. Muratova
    • 1
  • V. V. Godovan
    • 1
  • L. S. Godlevsky
    • 1
  • E. V. Kobolev
    • 1
  1. 1.Odessa National Medical University, Ministry of Public Health of UkraineOdessaUkraine

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