, Volume 46, Issue 1, pp 25–32 | Cite as

Analysis of Long-Term Depression in the Purkinje Cell Circuit (a Model Study)

  • X. C. Zhang
  • S. Q. Liu
  • H. X. Ren
  • Y. J. Zeng
  • G. X. Zhan

In the cerebellum, long-term depression (LTD) plays a key function in sculpting neuronal circuits to store information, since motor learning and memory are thought to be associated with such long-term changes in synaptic efficacy. To better understand the principles of transmission of information in the cerebellum, we, in our model, distinguished different types of neurons (type 1- and type 2-like) to examine the neuronal excitability and analyze the interspike interval (ISI) bifurcation phenomenon in these units, and then built a Purkinje cell circuit to study the impact of external stimulation on LTD in this circuit. According to the results of computational analysis, both climbing fiber-Purkinje cell and granule cell-Purkinje cell circuits were found to manifest LTD; the external stimuli would influence LTD by changing both depression time and depression intensity. All of the simulated results showed that LTD is a very significant factor in the Purkinje circuit networks. Finally, to deliver the learning regularities, we simulated spike timing-dependent plasticity (STDP) by increasing the CaP conductance.


long-term depression (LTD) interspike interval (ISI) ion currents depression time depression intensity spike timing-dependent plasticity (STDP) 


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of MathematicsSouth China University of TechnologyGuangzhouChina
  2. 2.Biomedical Engineering CenterBeijing University of TechnologyBeijingChina

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