Effect of Microiontophoretic Application of Modulators of Noradrenergic Transmission on Impulse Activity of Neurons of the Cat Motor Cortex during Performance of the Reflex to a Complex of Stimuli
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On unanesthetized cats, we studied the effects of selective modulators of noradrenergic transmission on the activity of neurons of the cerebral motor cortex in the course of realization of an operant motor reflex to presentation of a complex of stimuli. These modulators were applied using microiontophoretic injections into sites of recording of impulse activity of cortical neurons within the zone of projection of the “working” forelimb. Applications of the α1 receptor agonist Mesaton resulted in significant suppression of background impulsation of the neurons and spiking within the interstimulus interval immediately during realization of the movement. Under the action of the α2 blocker yohimbine, opposite effects were observed. The activity of neurons increased within both background period and other examined time intervals. Mechanisms of the effects of modulation of noradrenergic transmission in the sensorimotor cortex are discussed.
Keywordsoperant motor reflex slow cortical potential α1 and α2 adrenoreceptors Mesaton yohimbine
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- 1.G. Walter, The Living Brain [Russian translation], Mir, Moscow (1966).Google Scholar
- 4.J. I. Tecce, “Attention and evoked potentials in man,” in: Attention: Contemporary Theory and Analysis, D. I. Mostofsky (ed.), Appleton-Century-Crofts, New York (1966), pp. 331–365.Google Scholar
- 5.L. Gilden, Jr. Vaugham, and D. Costal, “Summated human EEG potentials with voluntary movement,” Electroencephalogr. Clin. Neurophysiol., 20, No. 14, 697–717 (1966).Google Scholar
- 8.B. I. Kotlyar, V. I. Maiorov, and E. I. Savchenko, “Models of learning based on plastic properties of ‘reaction of the support’ in cats,” Zh. Vyssh. Nerv. Deyat., 25, No. 5, 967–973 (1975).Google Scholar
- 9.P. V. Avdonin and V. A. Tkachyuk, Receptors and Intracellular Calcium [in Russian], Nauka, Moscow (1994).Google Scholar
- 11.D. Bai, G. Zhu, P. Pennefather, et al., “Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid (A) receptors in hippocampal neurons,” Med. Pharmacol., 59, No. 4, 814–824 (2001).Google Scholar
- 13.A. A. Aleksandrov, Technique of Microelectrophoresis in Physiology [in Russian], Nauka, Leningrad (1983).Google Scholar