Nature of Electrical Tristability in a Neuron Model with Bistable Asymmetrical Dendrites
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In a three-compartmental neuron model with two metrically asymmetrical dendrites, we defined the geometry-related conditions for the occurrence of electrical tristability of the cell. The modelled neuron contained a monostable passive soma and dendrites with the bistable membrane, whose active properties were due to the presence of NMDA-type channels responsible for a persistent inward current. The geometrical prerequisite for tristability was the metrical asymmetry due to the difference between the dendritic lengths. This feature caused unequal coupling of lateral currents, endowing the whole-cell input current-voltage relation with additional stable steady states. The existence of a certain range of geometrical parameters of the dendrites critical for whole-cell tristability was found.
Keywordsneuron models dendrites electrical properties metrical asymmetry electrical tristability
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- 1.A. M. Gutman, Dendrites of Nerve Cells. Theory, Electrophysiology, Function, Vilnius, Mokslas (1984).Google Scholar
- 10.S. M. Korogod, I. B. Kulagina, J. Durand, and S. Tyč-Dumont, “Electrical multistability of the dendritic arborization receiving tonic NMDA activation: a simulation study on reconstructed abducens motoneuron,” in: Proc. of the 3 rd Forum of European Neuroscience (Paris, Palais des Congres, July 13–17, FENS Abstr.), Vol. 1, A058.9 (2002).Google Scholar
- 13.M. Hines, “NEURON – a program for simulation of nerve equations,” in: Neural Systems: Analysis and Modeling, F. Eeckman (ed.), Kluwer Acad. Publ., Norwell MA (1993), pp. 127–136.Google Scholar