Hyperalgesic effect of emotional stress in mice of strains C57BL/6J and CBA/CaLac: Interaction with circadian rhythm-related effects
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We studied emotional stress-induced modulations of the pain reaction evoked in mice of strains C57BL/6J and CBA/CaLac by subcutaneous injections of formalin; the measurements were performed at midtimes of a “dark” and a “light” phase of the pre-set fixed circadian rhythm. The magnitude of the pain reaction was estimated indirectly, according to characteristics of locomotion of the animal in a running wheel (the velocity of locomotion and the distance covered were considered values inversely correlating with the intensity of the pain response). We found that the intensity of the pain reaction within both phases of the circadian rhythm increased under the influence of stress, and that there were significant differences between the emotional stress-modulated intensities of the pain response observed in the examined genetic strains of mice.
Keywordspain hyperalgesia circadian rhythm emotional stress mice of strains C57BL/6J and CBA/CaLac
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- 1.A. V. Kaluev, Problems of Studies of Stress-Related Behavior [in Russian], CSF, Kyiv (1999).Google Scholar
- 4.I. A. Arshavskii, Physiological Mechanisms and Regularities of Individual Development [in Russian], Nauka, Moscow (1982).Google Scholar
- 5.Z. K. Blandova, V. A. Doushkin, and A. M. Malashenko, Strains of Laboratory Animals Used in Medical/Biological Studies [in Russian], Nauka, Moscow (1983).Google Scholar
- 6.A. J. Greenshaw, T. V. Nguyen, and D. J. Sander, “Animal models for assessing anxiolytic, neuroleptic, and antidepressant drug action,” Neuromethods, 10, 379–427 (1988).Google Scholar
- 7.J. Bureš, O. Burešova, and J. Hewstone, Techniques and Basic Experiments for Studying the Brain and Behavior [Russian translation], Nauka, Moscow (1991).Google Scholar
- 12.R. D. Porsolt, R. A. McArthur, and A. Lenegre, “Psychotropic screening producers,” in: Methods in Behavioral Pharmacology, F. Van Haaren (ed.), Academic Press, New York (1993), pp. 23–51.Google Scholar