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Preoperative predictive factors affecting return to work in patients with gliomas undergoing awake brain mapping

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Abstract

Purpose

This study aimed to investigate the preoperative predictive factors affecting return to work in patients with gliomas in the left cerebral hemisphere undergoing awake surgery.

Methods

We retrospectively reviewed 50 consecutive glioma patients who underwent awake surgery from January 2012 to July 2017. Adult patients older than 18 years, who reported working prior to surgery, were recruited for this study.

Results

Comparing sociodemographic, disease-related and preoperative neurocognitive variables of glioma patients who returned to work and those who did not, binomial logistic regression models for preoperative predictors affecting return to work revealed significant differences in age and sole breadwinner status as sociodemographic variables, tumour volume as a disease-related variable, and Verbal IQ, Performance IQ, general memory, attention/concentration, and working memory as neurocognitive variables. Multivariate logistic regression models demonstrated that the independent factors associated with propriety of returning to work 1 year after surgery was the sociodemographic variable sole breadwinner status (yes vs no; OR = 15.00, 95% CI 2.22–101.35, p = 0.01), the disease-related variable tumour volume (per 1 cm3; OR = 0.98, 95% CI 0.96–0.99, p = 0.04), and the preoperative neurocognitive variable general memory (≥ 100 vs < 100; OR = 21.70, 95% CI 2.60–183.94, p = 0.01).

Conclusions

Our results suggest that three predictive factors including sole breadwinner status, tumour volume and general memory that can be assessed in the preoperative stage substantially contribute to returning to work in patients with gliomas in the left cerebral hemisphere, 1 year after awake surgery.

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Acknowledgements

The authors would like to thank Mrs. Junko Sugiura, Mr. Hiroyasu Yamamoto, Mr. Kyohei Koyama, and Mr. Yasuyuki Matsui (Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan) for their wonderful technical assistance.

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Authors and Affiliations

  1. Department of Rehabilitation Science, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Akihito Yoshida

  2. Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Kazuya Motomura, Atsushi Natsume, Lushun Chalise, Kentaro Iijima & Toshihiko Wakabayashi

  3. Department of Rehabilitation, Nagoya University Hospital, Nagoya, Japan

    Akihito Yoshida, Daisuke Hara & Izumi Kadono

  4. Department of Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan

    Kenji Wakai

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  1. Akihito Yoshida
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Correspondence to Kazuya Motomura.

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Conflict of interest

This work was supported by a Grant-in-Aid for Scientific Research (C) to K.M. (Grant No. 17K10862) from the Japan Society for the Promotion of Science (JSPS). We have no conflict of interest to declare for this study.

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Yoshida, A., Motomura, K., Natsume, A. et al. Preoperative predictive factors affecting return to work in patients with gliomas undergoing awake brain mapping. J Neurooncol 146, 195–205 (2020). https://doi.org/10.1007/s11060-019-03371-0

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