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Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center

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Abstract

Purpose

Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB.

Methods

Clinical data of 13 consecutive CB patients who received surgical treatment in our center between January 2006 and December 2016 were reviewed retrospectively. Recurrence-free survival (RFS) was estimated by Kaplan–Meier method and Log-rank test.

Results

The 13 CB patients included 9 men and 4 women with a mean age of 32 years. The lesions were located in the cervical spine in 2 cases, thoracic spine in 5 cases, and lumbar spine in 6 cases. All the patients were treated surgically using either curettage, piecemeal total resection, or TES. Postoperative radiotherapy was administered in 2 cases. The mean follow-up period was 41.6 months. Relapse occurred in 3 (23.1%) cases, resulting in one death in 60 months. The mean RFS duration was 28.7 months.

Conclusions

CB predominantly affects males and various age groups. Spinal CB more commonly involves the thoracic and lumbar segments. Spinal CB usually appears as an aggressive and destructive bony lesion with a soft tissue mass on imaging, forming compression on the spinal cord in some cases. Recurrence is not uncommon for spinal CB. Total resection, especially TES, has been confirmed as a powerful method to control the disease, while curettage is more likely to associate with local recurrence. Radiotherapy does not seem to reduce local recurrence.

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Author notes

  1. Qi Jia, Chao Liu and Jian Yang have contributed equally to this work, and all should be considered first author.

Authors and Affiliations

  1. Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Huangpu District, Shanghai, China

    Qi Jia, Chao Liu, Jian Yang, Yong Ji, Haifeng Wei, Tielong Liu, Xinghai Yang, Cheng Yang & Jianru Xiao

Authors
  1. Qi Jia
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  2. Chao Liu
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  3. Jian Yang
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  4. Yong Ji
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  5. Haifeng Wei
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  6. Tielong Liu
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  7. Xinghai Yang
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  8. Cheng Yang
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Corresponding authors

Correspondence to Xinghai Yang, Cheng Yang or Jianru Xiao.

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Conflict of interest

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript. No conflict of interest exists in the submission of this manuscript for all authors, and manuscript is approved by all authors for publication

Funding

This work was supported by Grants from National Key Research and Development Program of China (2016YFC0902100).

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Jia, Q., Liu, C., Yang, J. et al. Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center. J Neurooncol 140, 99–106 (2018). https://doi.org/10.1007/s11060-018-2935-0

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  • DOI: https://doi.org/10.1007/s11060-018-2935-0

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