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Journal of Neuro-Oncology

, Volume 139, Issue 1, pp 97–106 | Cite as

Glioblastoma (GBM) effects on quantitative MRI of contralateral normal appearing white matter

  • Hatef Mehrabian
  • Wilfred W. Lam
  • Sten Myrehaug
  • Arjun Sahgal
  • Greg J. Stanisz
Clinical Study
  • 288 Downloads

Abstract

Purpose

The objective was to investigate (with quantitative MRI) whether the normal appearing white matter (NAWM) of glioblastoma (GBM) patients on the contralateral side (cNAWM) was different from NAWM of healthy controls.

Methods

Thirteen patients with newly diagnosed GBM and nine healthy age-matched controls were MRI-scanned with quantitative magnetization transfer (qMT), chemical exchange saturation transfer (CEST), and transverse relaxation time (T2)-mapping. MRI scans were performed after surgery and before chemo-radiation treatment. Comprehensive qMT, CEST, T2 data were acquired. A two-pool MT model was fit to qMT data in transient state, to calculate MT model parameters \([{\text{R}},\,{{\text{T}}_{2{\text{b}}}},{\text{ R}}{{\text{M}}_{0{\text{b}}}}/{{\text{R}}_{\text{a}}},\,1/{{\text{R}}_{\text{a}}}{{\text{T}}_{2{\text{a}}}}]\). CEST signal was isolated by removing the contributions from the MT and direct water saturation, and CEST signal was calculated for Amide (CESTAmide), Amine (CESTAmine) and nuclear overhauser effect, NOE (CESTNOE).

Results

There was no difference between GBM patients and normal controls in the qMT properties of the macromolecular pool \(({\text{R}},\,{{\text{T}}_{2{\text{b}}}},{\text{ R}}{{\text{M}}_{0{\text{b}}}}/{{\text{R}}_{\text{a}}})\). However, their free water pool spectrum was different (1/RaT2a,patient = 28.1 ± 3.9, 1/RaT2a,control = 25.0 ± 1.1, p = 0.03). This difference could be attributed to the difference in their T2 time (\(T_{{2,\;{\text{patient}}}}^{{{\text{obs}}}}\) = 83 ± 4, \({T}_{{2,\;{\text{control}}}}^{{{\text{obs}}}}\) = 88 ± 1, p = 0.004). CEST signals were statistically significantly different with the CESTAmide having the largest difference between the two cohorts (CESTAmide,patient = 2.8 ± 0.4, CESTAmide,control = 3.4 ± 0.5, p = 0.009).

Conclusions

CEST in cNAWM of GBM patients was lower than healthy controls which could be caused by modified brain metabolism due to tumor cell infiltration. There was no difference in MT properties of the patients and controls, however, the differences in free water pool properties were mainly due to reduced T2 in cNAWM of the patients (resulting from structural changes and increased cellularity).

Keywords

Quantitative magnetization transfer (qMT) Chemical exchange saturation transfer (CEST) Glioblastoma (GBM) Normal appearing white matter (NAWM) 

Notes

Acknowledgements

This study was funded by Terry Fox Research Institute (TFRI project 1034), Canadian Cancer Society Research Institute (CCSRI 701640) and Brain Canada Grant (CCSRI 705083).

Compliance with ethical standards

Conflict of interest

The authors declare no potential conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medical BiophysicsUniversity of TorontoTorontoCanada
  2. 2.Physical SciencesSunnybrook Research InstituteTorontoCanada
  3. 3.Radiation OncologySunnybrook Health Sciences CentreTorontoCanada
  4. 4.Department of Radiation OncologyUniversity of TorontoTorontoCanada
  5. 5.Department of Neurosurgery and Pediatric NeurosurgeryMedical UniversityLublinPoland
  6. 6.Radiology and Biomedical ImagingUniversity of California, San Francisco (UCSF)San FranciscoUSA

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