Journal of Neuro-Oncology

, Volume 135, Issue 1, pp 141–150 | Cite as

Design fluency and neuroanatomical correlates in 54 neurosurgical patients with lesions to the right hemisphere

  • Dario Marin
  • Eleonora Madotto
  • Franco Fabbro
  • Miran Skrap
  • Barbara Tomasino
Clinical Study
  • 129 Downloads

Abstract

We addressed the neuroanatomical correlates of 54 right-brain-damaged neurosurgical patients on visuo-spatial design fluency, which is a measure of the ability to generate/plan a series of new abstract combinations in a flexible way. 22.2% of the patients were impaired. They failed the task because they did not use strategic behavior, in particular they used rotational strategy to a significantly lower extent and produced a significantly higher rate of perseverative errors. Overall performance did not correlate with neuropsychological tests, suggesting that proficient performance was independent of other cognitive domains. Performance significantly correlated with use of rotational strategy. Tasks related to executive functions such as psychomotor speed and capacity to shift were positively correlated to the number of strategies used to solve the task. Lesion analysis showed that the maximum density of the patients’ lesions—obtained by subtracting the overlap of lesions of spared patients from the overlap of lesions of impaired patients—overlaps with the precentral gyrus, rolandic operculum/insula, superior/middle temporal gyrus/hippocampus and, at subcortical level, with part of the superior longitudinal fasciculus, external capsule, retrolenticular part of the internal capsule and sagittal stratum (inferior longitudinal fasciculus and inferior fronto–occipital fasciculus). These areas are part of the fronto–parietal–temporal network known to be involved in top–down control of visuo-spatial attention, suggesting that the mechanisms and the strategies needed for proficient performance are essentially visuo-spatial in nature.

Keywords

Design fluency Five-point test MRI Neurosurgical patients Lesion mapping 

Supplementary material

11060_2017_2560_MOESM1_ESM.docx (47 kb)
Supplementary material 1 (DOCX 46 KB)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.IRCCS “E. Medea”Polo Regionale del Friuli Venezia GiuliaSan Vito al Tagliamento (PN)Italy
  2. 2.Dipartimento di Medicina e ChirurgiaUniversità di UdineUdineItaly
  3. 3.Unità Operativa di NeurochirurgiaAzienda Sanitaria Universitaria Integrata S. Maria della MisericordiaUdineItaly

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