Advertisement

Journal of Neuro-Oncology

, Volume 135, Issue 1, pp 57–65 | Cite as

Clinical, radiological, pathological and prognostic aspects of intraventricular oligodendroglioma: comparison with central neurocytoma

  • Xiang Xiao
  • Jun Zhou
  • Jun Wang
  • Lei Yang
  • Chunhong Wang
  • Yikai Xu
  • Yuankui Wu
Clinical Study

Abstract

Studies comparing intraventricular oligodendroglioma (IVO) and central neurocytoma (CN) in terms of their clinical, radiological and pathological features are scarce. We, therefore, investigated the similarities and differences between these types of tumors to get a better understanding of how they may be more properly diagnosed and treated. The clinical manifestations, CT/MRI findings, pathological characteristics and clinical outcomes of 8 cases of IVOs and 12 cases of CNs were analyzed retrospectively. Both IVO and CN occurred most commonly in young adults and manifested with symptoms of increased intracranial pressure secondary to obstructive hydrocephalus. However, they were radiologically different in location (p = 0.007), diffusion-weighted imaging (p = 0.001), “scalloping” appearance (p = 0.006), flow void sign (p = 0.006) and ventricular wall invasion (p = 0.000). Histologically, significant differences in mitotic count (p = 0.008) and parenchymal infiltration (p = 0.01) were noted. Immunohistochemically, significant differences in the expression of Olig2 (p = 0.000), Syn (p = 0.01) and NeuN (p = 0.000) were observed. In addition, MIB-1 labeling index (p = 0.035) and case fatality rate (p = 0.021) of IVO were much higher than those of CN, while survival rate of IVO was much lower than that of CN (p = 0.028). IVO and CN are similar in onset age and clinical manifestations, but have different imaging and pathological features. Patients with IVOs may have a relatively poorer prognosis compared to those with CNs.

Keywords

Oligodendroglioma Central neurocytoma Radiology Pathology Prognosis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conlict of interest.

Ethical approval

All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation of Southern Medical University, Guangzhou, China, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

11060_2017_2490_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 16 KB)

References

  1. 1.
    Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820CrossRefPubMedGoogle Scholar
  2. 2.
    Maiuri F, Giamundo A, Di Prisco B (1982) Primary intraventricular oligodendroglioma. Surg Neurol 18:364–366CrossRefPubMedGoogle Scholar
  3. 3.
    Dolinskas CA, Simeone FA (1987) CT characteristics of intraventricular oligodendrogliomas. Am J Neuroradiol 8:1077–1082PubMedGoogle Scholar
  4. 4.
    Dickson W (1926) Oligodendroglioma of the 3rd ventricle. Brain 49:578–580CrossRefGoogle Scholar
  5. 5.
    Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G et al (1982) Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathologica 56:151–156CrossRefPubMedGoogle Scholar
  6. 6.
    Choudhari KA, Kaliaperumal C, Jain A, Sarkar C, Soo M et al (2009) Central neurocytoma: a multi-disciplinary review. B J Neurosurg 23:585–595CrossRefGoogle Scholar
  7. 7.
    Schmidt MH, Gottfried ON, von Koch CS, Chang SM, McDermott MW (2004) Central neurocytoma: a review. J Neurooncol 66:377–384CrossRefPubMedGoogle Scholar
  8. 8.
    Sharma MC, Deb P, Sharma S, Sarkar C (2006) Neurocytoma: a comprehensive review. Neurosurg Rev 29:270–285CrossRefPubMedGoogle Scholar
  9. 9.
    Hasuo K, Fukui M, Tamura S, Yasumori K, Uchino A et al (1987) Oligodendrogliomas of the lateral ventricle: computed tomography and angiography. J Comput Tomogr 11:376–382CrossRefPubMedGoogle Scholar
  10. 10.
    Lee KS, Kelly DJ (1990) Primary oligodendroglioma of the lateral ventricle. South Med J 83:254–255CrossRefPubMedGoogle Scholar
  11. 11.
    Yuen ST, Fung CF, Ng TH, Leung SY (1992) Central neurocytoma: its differentiation from intraventricular oligodendroglioma. Child Nerv Syst 8:383–388CrossRefGoogle Scholar
  12. 12.
    Atalay B, Altinors N, Caner H, Bavbek M, Cekinmez M, Hasturk A (2002) Primary biventricular oligodendroglioma. Turk Neurosurg 12:138–139Google Scholar
  13. 13.
    Natale M, Spennato P, Savarese L, Bocchetti A, Esposito S, Barbato R (2005) Anaplastic oligodendroglioma presenting with drop metastases in the cauda equina. Clin Neurol Neurosurg 107:417–420CrossRefPubMedGoogle Scholar
  14. 14.
    Zada G, McNatt SA, Gonzalez-Gomez I, McComb JG (2009) Anaplastic intraventricular oligodendroglioma: case report and review of the literature. Surg Neurol 71:693–700CrossRefPubMedGoogle Scholar
  15. 15.
    Matsumoto H, Yoshida Y (2015) Primary intraventricular oligodendroglioma: a case report of the usefulness of Olig2 immunohistochemistry for diagnosis. Neuropathology 35:553–560CrossRefPubMedGoogle Scholar
  16. 16.
    Pomero E, La Piana R, Cortes MDP, Tampieri D (2012) Intraventricular Localization of an anaplastic oligodedendroglioma: a rare event. Can J Neurol Sci 39:649–651CrossRefPubMedGoogle Scholar
  17. 17.
    Kim JW, Kim DG, Kim IK, Kim YH, Choi SH et al (2013) Central neurocytoma: long-term outcomes of multimodal treatments and management strategies based on 30 years’ experience in a single institute. Neurosurgery 72:407–413CrossRefPubMedGoogle Scholar
  18. 18.
    von Deimling A, Janzer R, Kleihues P, Wiestler OD (1990) Patterns of differentiation in central neurocytoma. An immunohistochemical study of eleven biopsies. Acta Neuropathol 79:473–479CrossRefGoogle Scholar
  19. 19.
    Kendall B, Reider-Grosswasser I, Valentine A (1983) Diagnosis of masses presenting within the ventricles on computed tomography. Neuroradiology 25:11–22CrossRefPubMedGoogle Scholar
  20. 20.
    Bradac GB, Ferszt R, Bender A, Schorner W (1986) Peritumoral edema in meningiomas. A radiological and histological study. Neuroradiology 28:304–312CrossRefPubMedGoogle Scholar
  21. 21.
    Schmid UD, Seiler RW (1986) Management of obstructive hydrocephalus secondary to posterior fossa tumors by steroids and subcutaneous ventricular catheter reservoir. J Neurosurg 65:649–653CrossRefPubMedGoogle Scholar
  22. 22.
    Chen CL, Shen CC, Wang J, Lu CH, Lee HT (2008) Central neurocytoma: a clinical, radiological and pathological study of nine cases. Clin Neurol Neurosurg 110:129–136CrossRefPubMedGoogle Scholar
  23. 23.
    Yang I, Ung N, Chung LK, Nagasawa DT, Thill K et al (2015) Clinical manifestations of central neurocytoma. Neurosurg Clin N Am 26:5–10CrossRefPubMedGoogle Scholar
  24. 24.
    Patel DM, Schmidt RF, Liu JK (2013) Update on the diagnosis, pathogenesis, and treatment strategies for central neurocytoma. J Clin Neurosci 20:1193–1199CrossRefPubMedGoogle Scholar
  25. 25.
    Jaiswal S, Vij M, Rajput D, Mehrotra A, Jaiswal AK et al (2011) A clinicopathological, immunohistochemical and neuroradiological study of eight patients with central neurocytoma. J Clin Neurosci 18:334–339CrossRefPubMedGoogle Scholar
  26. 26.
    Chen HH, Zhou RR, Liu JY, Tang JT (2012) Central neurocytoma. J Clin Neurosci 19:849–853CrossRefPubMedGoogle Scholar
  27. 27.
    Niiro T, Tokimura H, Hanaya R, Hirano H, Fukukura Y et al (2012) MRI findings in patients with central neurocytomas with special reference to differential diagnosis from other ventricular tumours near the foramen of Monro. J Clin Neurosci 19:681–686CrossRefPubMedGoogle Scholar
  28. 28.
    Zhang B, Luo BN, Zhang ZW, Sun GX, Wen JM (2004) Central neurocytoma: a clinicopathological and neuroradiological study. Neuroradiology 46:888–895CrossRefPubMedGoogle Scholar
  29. 29.
    Tlili-Graiess K, Mama N, Arifa N, Kadri K, Hasni I et al (2014) Diffusion weighted MR imaging and proton MR spectroscopy findings of central neurocytoma with pathological correlation. J Neuroradiol 41:243–350CrossRefPubMedGoogle Scholar
  30. 30.
    Engelhard HH, Stelea A, Cochran EJ (2002) Oligodendroglioma: pathology and molecular biology. Surg Neurol 58:111–117CrossRefPubMedGoogle Scholar
  31. 31.
    Sharma MC, Sarkar C, Karak AK, Gaikwad S, Mahapatra AK, Mehta VS (1999) Intraventricular neurocytoma: a clinicopathological study of 20 cases with review of the literature. J Clin Neurosci 6:319–323CrossRefPubMedGoogle Scholar
  32. 32.
    Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M et al (2001) Olig2 as a specific marker of oligodendroglialtumour cells. Lancet 358:298–300CrossRefPubMedGoogle Scholar
  33. 33.
    Yokoo HYMG, Nobusawa S, Takebayashi H, Ikenaka K, Isoda K et al (2004) Anti-human olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. Am J Pathol 164:1717–1725CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P (1993) Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol 3:297–306CrossRefPubMedGoogle Scholar
  35. 35.
    Soylemezoglu F, Onder S, Tezel GG, Berker M (2003) Neuronal nuclear antigen (NeuN): a new tool in the diagnosis of central neurocytoma. Pathol Res Pract 199:463–468CrossRefPubMedGoogle Scholar
  36. 36.
    Preusser M, Laggner U, Haberler C, Heinzl H, Budka H, Hainfellner JA (2006) Comparative analysis of NeuN immunoreactivity in primary brain tumours: conclusions for rational use in diagnostic histopathology. Histopathology 48:438–444CrossRefPubMedGoogle Scholar
  37. 37.
    Ishiuchi S, Tamura M (1997) Central neurocytoma: an immunohistochemical, ultrastructural and cell culture study. Acta Neuropathol 94:425–435CrossRefPubMedGoogle Scholar
  38. 38.
    Tsuchida T, Matsumoto M, Shirayama Y, Imahori T, Kasai H, Kawamoto K (1996) Neuronal and glial characteristics of central neurocytoma: electron microscopical analysis of two cases. Acta Neuropathol 91:573–577CrossRefPubMedGoogle Scholar
  39. 39.
    Elek G, Slowik F, Eross L, Toth S, Szabo Z, Balint K (1999) Central neurocytoma with malignant course. Neuronal and glial differentiation and craniospinal dissemination. Pathol Oncol Res 5:155–159CrossRefPubMedGoogle Scholar
  40. 40.
    Brandes AA, Amista P, Gardiman M, Volpin L, Danieli D et al (2000) Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer 88:169–174CrossRefPubMedGoogle Scholar
  41. 41.
    Vasiljevic A, Francois P, Loundou A, Fevre-Montange M, Jouvet A et al (2012) Prognostic factors in central neurocytomas: a multicenter study of 71 cases. Am J Surg Pathol 36:220–227CrossRefPubMedGoogle Scholar
  42. 42.
    Rades D, Fehlauer F (2002) Treatment options for central neurocytoma. Neurology 59:1268–1270CrossRefPubMedGoogle Scholar
  43. 43.
    Imber BS, Braunstein SE, Wu FY, Nabavizadeh N, Boehling N et al (2016) Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience. J Neurooncol 126:193–200CrossRefPubMedPubMedCentralGoogle Scholar
  44. 44.
    Mackenzie IR (1999) Central neurocytoma: histologic atypia, proliferation potential, and clinical outcome. Cancer 85:1606–1610CrossRefPubMedGoogle Scholar
  45. 45.
    Rades D, Schild SE (2006) Treatment recommendations for the various subgroups of neurocytomas. J Neurooncol 77:305–309CrossRefPubMedGoogle Scholar
  46. 46.
    Rades D, Schild SE, Fehlauer F (2004) Prognostic value of the MIB-1 labeling index for central neurocytomas. Neurology 62:987–989CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Medical Imaging Center, Nanfang HospitalSouthern Medical UniversityGuangzhouChina
  2. 2.Department of Pathology, Nanfang HospitalSouthern Medical UniversityGuangzhouChina
  3. 3.Department of Neurosurgery, Nanfang HospitalSouthern Medical UniversityGuangzhouChina

Personalised recommendations