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Journal of Neuro-Oncology

, Volume 122, Issue 1, pp 217–218 | Cite as

Anaplastic oligoastrocytoma: is molecular stratification based on 1p/19q status alone appropriate?

  • Yingjie Zou
  • Harrison Xiao Bai
  • Yi Shu
  • Chao Mao
  • Bin Yan
  • Li Yang
Letter to the Editor

To the Editor,

We read with interest a recent paper published by Jiang et al. on molecular classification for high-grade oligodendroglial tumors (HGOs) based on 1p/19q status. Using 117 tumors with histological diagnosis of primary HGOs, the authors divided these patients into four subtypes which conferred remarkably distinct prognosis based on the number of risk factors (higher tumor grade, 1p/19q maintenance and 1q/19p copolysomy). The authors concluded that the molecular classification scheme based on 1p/19q status alone can serve as a supplement of the current World Health Organization classification system and contribute to the personalized treatment decision-making.

An oligoastrocytoma (OA) is defined as a tumor with a conspicuous mixture of two distinct neoplastic cell types resembling oligodendrocytes and astrocytes. Due to the heterogenous morphology, the histological diagnosis of OA is often subjective. No guidelines currently exist regarding the minimum percentage of either...

Keywords

Astrocytoma Oligodendroglial Tumor Diffuse Glioma Anaplastic Oligoastrocytoma Current World Health Organization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by the Natural Science Foundation of China (81301988 to L.Y.), and China Ministry of Education Doctoral Program Spot Foundation (20130162120061 to L.Y.).

References

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    Kraus JA, Koopmann J, Kaskel P et al (1995) Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropathol Exp Neurol 54:91–95CrossRefPubMedGoogle Scholar
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    Qu M, Olofsson T, Sigurdardottir S et al (2007) Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas. Acta Neuropathol 113:129–136CrossRefPubMedGoogle Scholar
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    Sahm F, Reuss D, Koelsche C et al (2014) Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropathol 128:519–551CrossRefGoogle Scholar
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    Louis DN, Perry A, Burger P et al (2014) International Society of Neuropathology-Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol 24:429–443CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yingjie Zou
    • 1
  • Harrison Xiao Bai
    • 2
  • Yi Shu
    • 3
  • Chao Mao
    • 4
  • Bin Yan
    • 4
  • Li Yang
    • 1
  1. 1.Department of Neurology, The Second Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China
  2. 2.Department of RadiologyHospital of the University of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Neurology, The Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China
  4. 4.Cancer Research Institute of Xiangya School of MedicineCentral South UniversityChangshaPeople’s Republic of China

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