Anaplastic oligoastrocytoma: is molecular stratification based on 1p/19q status alone appropriate?
- 215 Downloads
To the Editor,
We read with interest a recent paper published by Jiang et al. on molecular classification for high-grade oligodendroglial tumors (HGOs) based on 1p/19q status. Using 117 tumors with histological diagnosis of primary HGOs, the authors divided these patients into four subtypes which conferred remarkably distinct prognosis based on the number of risk factors (higher tumor grade, 1p/19q maintenance and 1q/19p copolysomy). The authors concluded that the molecular classification scheme based on 1p/19q status alone can serve as a supplement of the current World Health Organization classification system and contribute to the personalized treatment decision-making.
An oligoastrocytoma (OA) is defined as a tumor with a conspicuous mixture of two distinct neoplastic cell types resembling oligodendrocytes and astrocytes. Due to the heterogenous morphology, the histological diagnosis of OA is often subjective. No guidelines currently exist regarding the minimum percentage of either...
KeywordsAstrocytoma Oligodendroglial Tumor Diffuse Glioma Anaplastic Oligoastrocytoma Current World Health Organization
This work was supported by the Natural Science Foundation of China (81301988 to L.Y.), and China Ministry of Education Doctoral Program Spot Foundation (20130162120061 to L.Y.).