Journal of Neuro-Oncology

, Volume 121, Issue 3, pp 425–431 | Cite as

MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma

Laboratory Investigation


Glioblastomas (GBMs) are the highest grade of primary brain tumors with astrocytic similarity and are characterized dispersal of tumor cell. Metastasis suppressor 1 (MTSS1) play an important role in cancer metastasis. Recent studies indicating that MTSS1 as a potential tumor suppressor and its reduced expression associated with poor prognosis in many cancer types. However, the relationship with the prognosis of patients and the molecular mechanism of MTSS1 renders a tumor suppressor effect in GBM is unknown. Here, we showed that low MTSS1 gene expression is associated with poor outcomes in patients with GBM. Overexpression of MTSS1 in U-87 MG cells exhibited inhibited glioma cell growth, colony formation, migration and invasion. Mechanistically, we found that high MTSS1 expression in U-87 MG reduced expression of CTTN. These results implicate that the role of MTSS1 suppresses cell migration and invasion by inhibiting expression of CTTN and as a prognosis biomarker in GBM.


MTSS1 Tumor suppressor CTTN Glioblastoma 



We thank Reynolds JL for providing the NHA cell. Chenyuan For helpful discussion, and Zhangyuan for technical assistance.

Conflict of interest

The authors declared that they have no conflicts of interest to this work.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of NeurosurgeryThe First Affiliated Hospital of Liaoning Medical UniversityJinzhouChina
  2. 2.Cancer Center, Research Institute of Surgery and Daping HospitalThird Military Medical UniversityChongqingChina

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