Abstract
Glioblastomas (GBMs) are the highest grade of primary brain tumors with astrocytic similarity and are characterized dispersal of tumor cell. Metastasis suppressor 1 (MTSS1) play an important role in cancer metastasis. Recent studies indicating that MTSS1 as a potential tumor suppressor and its reduced expression associated with poor prognosis in many cancer types. However, the relationship with the prognosis of patients and the molecular mechanism of MTSS1 renders a tumor suppressor effect in GBM is unknown. Here, we showed that low MTSS1 gene expression is associated with poor outcomes in patients with GBM. Overexpression of MTSS1 in U-87 MG cells exhibited inhibited glioma cell growth, colony formation, migration and invasion. Mechanistically, we found that high MTSS1 expression in U-87 MG reduced expression of CTTN. These results implicate that the role of MTSS1 suppresses cell migration and invasion by inhibiting expression of CTTN and as a prognosis biomarker in GBM.
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Acknowledgments
We thank Reynolds JL for providing the NHA cell. Chenyuan For helpful discussion, and Zhangyuan for technical assistance.
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The authors declared that they have no conflicts of interest to this work.
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Qigui Qi has contributed equally to this work.
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Zhang, S., Qi, Q. MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma. J Neurooncol 121, 425–431 (2015). https://doi.org/10.1007/s11060-014-1656-2
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DOI: https://doi.org/10.1007/s11060-014-1656-2