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Journal of Neuro-Oncology

, Volume 116, Issue 1, pp 107–111 | Cite as

Fractionated stereotactic radiosurgery for recurrent ependymoma in children

  • Lindsey M. Hoffman
  • S. Reed Plimpton
  • Nicholas K. Foreman
  • Nicholas V. Stence
  • Todd C. Hankinson
  • Michael H. Handler
  • Molly S. Hemenway
  • Rajeev Vibhakar
  • Arthur K. Liu
Clinical Study

Abstract

Outcomes for children with relapsed ependymoma are poor. Re-irradiation is a potentially viable salvage option in these patients. Data were reviewed for 12 patients (median age 5.6 years) with relapsed ependymoma who received fractionated stereotactic radiosurgery (fSRS) following maximal surgical resection from 1995 to 2012. Four patients experienced a second recurrence, including 2 in-field and 2 distant failures. Median time to second recurrence (32 months) was significantly longer than time to first recurrence (24 months) (p = 0.008). Three-year local control was 89 %, and median event free survival from fSRS was 3.4 years. Radiation necrosis was observed in 6 patients, 3 who were symptomatic. In conclusion, fSRS offers durable response with a tolerable toxicity profile in children with recurrent EPN.

Keywords

Ependymoma Stereotactic radiosurgery Pediatric Recurrent 

Notes

Acknowledgments

Grant funding was provided by the NIH Ruth L. Kirschstein National Research Service Award (T32 CA 82086-13).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Lindsey M. Hoffman
    • 1
    • 5
  • S. Reed Plimpton
    • 2
  • Nicholas K. Foreman
    • 1
  • Nicholas V. Stence
    • 3
  • Todd C. Hankinson
    • 4
  • Michael H. Handler
    • 4
  • Molly S. Hemenway
    • 1
  • Rajeev Vibhakar
    • 1
  • Arthur K. Liu
    • 2
  1. 1.Department of PediatricsUniversity of Colorado DenverAuroraUSA
  2. 2.Department of Radiation OncologyUniversity of Colorado DenverAuroraUSA
  3. 3.Department of RadiologyUniversity of Colorado DenverAuroraUSA
  4. 4.Department of NeurosurgeryUniversity of Colorado DenverAuroraUSA
  5. 5.Children’s Hospital ColoradoAuroraUSA

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