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Journal of Neuro-Oncology

, Volume 115, Issue 1, pp 53–59 | Cite as

Clinical characteristics and prognostic analysis of recurrent hemangiopericytoma in the central nervous system: a review of 46 cases

  • Runfa Tian
  • Shuyu Hao
  • Zonggang Hou
  • Liheng Bian
  • Ying Zhang
  • Weichuan Wu
  • Feifan Xu
  • Huan Li
  • Baiyun Liu
Clinical Study

Abstract

Central nervous system hemangiopericytoma (HPC) is a malignant vascularized mesenchymal tumor with a high rate of recurrence. Because of its rarity, few clinical characteristics and prognostic analysis information regarding recurrent HPC exist for doctors to pursue optimal outcomes. Forty-six recurrent HPC cases treated at our hospital between 2004 and 2012 were compiled into a single database based on a retrospective review of patient records, which were used to summarize the clinical characteristics. The mean survival of the recurrent HPC patients in our cohort was 41.6 ± 4.4 months, with 1-, 2-, 3-, and 4-year survival rates of 80.4, 65.2, 59.2, and 53.8 %, respectively. Thirty patients (65.2 %) suffered their first tumor recurrence, with a mean survival of 36.9 ± 4.1 months. Sixteen patients (34.8 %) suffered a second or further tumor recurrence, with a mean survival of 39.7 ± 7.0 months. Eighteen patients (39.1 %) died of all causes during the follow-up period, with a mean survival of 14.2 ± 5.6 months. Univariate and multivariate regression analyses showed that factors associated with good prognosis included recurrence age over 35 years, an interval between the first and second recurrence of more than 1 year and a clear boundary of the recurrent tumor. Gross total resection with adjuvant external beam radiotherapy could independently delay tumor recurrence of the second or more times and prolong the postoperative survival; thus, this strategy should be pursued as the initial treatment.

Keywords

Central nervous system Recurrent Hemangiopericytoma Clinical characteristics Treatment Prognosis 

Notes

Acknowledgments

This study was supported by National Natural Science Foundation of China (No. 81171144) and Beijing Nova program (No. XX2012033).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Runfa Tian
    • 1
  • Shuyu Hao
    • 1
  • Zonggang Hou
    • 1
  • Liheng Bian
    • 2
  • Ying Zhang
    • 3
  • Weichuan Wu
    • 1
  • Feifan Xu
    • 1
  • Huan Li
    • 1
  • Baiyun Liu
    • 1
    • 3
    • 4
  1. 1.Department of Neurosurgery, Beijing Tiantan HospitalCapital Medical UniversityBeijingPeople’s Republic of China
  2. 2.Department of Neurology, Beijing Tiantan HospitalCapital Medical UniversityBeijingPeople’s Republic of China
  3. 3.Neurotrauma LaboratoryBeijing Neurosurgical Institute, Capital Medical UniversityBeijingPeople’s Republic of China
  4. 4.Department of NeurotraumaGeneral Hospital of Armed Police ForcesBeijingPeople’s Republic of China

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