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Stereotactic radiosurgery for brain metastases from hepatocellular carcinoma

  • Clinical Study
  • Published:
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Abstract

The purpose of this study is to investigate the possible role of stereotactic radiosurgery (SRS) in the management of patients with brain metastases from hepatocellular carcinoma (HCC). Thirty-two consecutive patients with 80 brain metastases from HCC were treated with SRS. Twenty-eight (87.5 %) patients were male, and the mean age of the patients was 54 ± 12 years (range 22–73). Twenty-seven (84.4 %) patients were classified as RTOG RPA Class 2. The mean tumor volume was 6.14 ± 11.3 cm3 (range 0.01–67.3). The mean marginal dose prescribed was 20.1 ± 3.6 Gy (range 10.0–25.0). The median overall survival time after SRS was 11.3 ± 5.8 weeks (95 % CI 0–22.7). A greater total volume of brain metastases (>14 cm3) was the only independent prognostic factor (HR = 2.419; 95 % CI 1.040–5.624; p = 0.040). The actuarial control rate of brain metastases was 51.3 % at 4 months after SRS. The prescribed marginal dose (>18 Gy) was significantly related with the actuarial tumor control (HR = 0.254; 95 % CI 0.089–0.725; p = 0.010). The prognosis of patients with brain metastases from HCC is dismal even with the modern technology of radiosurgery. The marginal dose prescribed should be reevaluated to improve upon the current poor local control rates.

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Acknowledgments

This study was supported by grant no. 02-2011-006 from the SNUBH Research Fund.

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Authors and Affiliations

  1. Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Seongnam, Korea

    Jung Ho Han, Chae-Yong Kim & Young-Hoon Kim

  2. Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea

    Dong Gyu Kim, Hyun-Tai Chung, Sun Ha Paek, Chul-Kee Park & Hee-Won Jung

  3. Department of Neurosurgery, Seoul National University College of Medicine, 101 Daehang-ro Jongno-gu, Seoul, 110-744, Korea

    Jung Ho Han, Dong Gyu Kim, Hyun-Tai Chung, Sun Ha Paek, Chul-Kee Park, Chae-Yong Kim, Young-Hoon Kim & Hee-Won Jung

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  1. Jung Ho Han
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Correspondence to Dong Gyu Kim.

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Han, J.H., Kim, D.G., Chung, HT. et al. Stereotactic radiosurgery for brain metastases from hepatocellular carcinoma. J Neurooncol 115, 45–51 (2013). https://doi.org/10.1007/s11060-013-1192-5

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  • DOI: https://doi.org/10.1007/s11060-013-1192-5

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