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Journal of Neuro-Oncology

, Volume 115, Issue 1, pp 45–51 | Cite as

Stereotactic radiosurgery for brain metastases from hepatocellular carcinoma

  • Jung Ho Han
  • Dong Gyu Kim
  • Hyun-Tai Chung
  • Sun Ha Paek
  • Chul-Kee Park
  • Chae-Yong Kim
  • Young-Hoon Kim
  • Hee-Won Jung
Clinical Study

Abstract

The purpose of this study is to investigate the possible role of stereotactic radiosurgery (SRS) in the management of patients with brain metastases from hepatocellular carcinoma (HCC). Thirty-two consecutive patients with 80 brain metastases from HCC were treated with SRS. Twenty-eight (87.5 %) patients were male, and the mean age of the patients was 54 ± 12 years (range 22–73). Twenty-seven (84.4 %) patients were classified as RTOG RPA Class 2. The mean tumor volume was 6.14 ± 11.3 cm3 (range 0.01–67.3). The mean marginal dose prescribed was 20.1 ± 3.6 Gy (range 10.0–25.0). The median overall survival time after SRS was 11.3 ± 5.8 weeks (95 % CI 0–22.7). A greater total volume of brain metastases (>14 cm3) was the only independent prognostic factor (HR = 2.419; 95 % CI 1.040–5.624; p = 0.040). The actuarial control rate of brain metastases was 51.3 % at 4 months after SRS. The prescribed marginal dose (>18 Gy) was significantly related with the actuarial tumor control (HR = 0.254; 95 % CI 0.089–0.725; p = 0.010). The prognosis of patients with brain metastases from HCC is dismal even with the modern technology of radiosurgery. The marginal dose prescribed should be reevaluated to improve upon the current poor local control rates.

Keywords

Stereotactic radiosurgery Hepatocellular carcinoma Brain metastases Stereotactic radiotherapy 

Notes

Acknowledgments

This study was supported by grant no. 02-2011-006 from the SNUBH Research Fund.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jung Ho Han
    • 1
    • 3
  • Dong Gyu Kim
    • 2
    • 3
  • Hyun-Tai Chung
    • 2
    • 3
  • Sun Ha Paek
    • 2
    • 3
  • Chul-Kee Park
    • 2
    • 3
  • Chae-Yong Kim
    • 1
    • 3
  • Young-Hoon Kim
    • 1
    • 3
  • Hee-Won Jung
    • 2
    • 3
  1. 1.Department of NeurosurgerySeoul National University Bundang HospitalSeongnamKorea
  2. 2.Department of NeurosurgerySeoul National University HospitalSeoulKorea
  3. 3.Department of NeurosurgerySeoul National University College of MedicineSeoulKorea

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