Journal of Neuro-Oncology

, Volume 113, Issue 2, pp 341–342 | Cite as

Unclear standard of care for pediatric high grade glioma patients

  • Jason Fangusaro
  • Katherine E. Warren
Letter to the Editor

To the Editor

Pediatric high grade gliomas (HGGs) are aggressive tumors with an unclear standard of care. However, there are many agreed upon treatment standards. The amount of surgical resection is one important clinical prognostic factor identified [1, 2]. The Children’s Cancer Group (CCG) study-945 revealed children who underwent a surgical resection of 90 % or greater had 5-year progression-free survival (PFS) of 35 + 7 % compared to 17 + 4 % in patients who did not [1]. Every attempt should be made at a complete surgical resection when safe to maximize survival. Also, for most children greater than 3 years old, focal radiotherapy has become standard. One of the main unanswered questions regarding the standard of care, however, surrounds the uncertain role of chemotherapy.

Children’s Cancer Group study-943 randomized children to either weekly vincristine during radiation (XRT) (54 Gy) followed by maintenance prednisone, lomustine, and vincristine (pCV) or XRT alone [3]. Five-year...


Bevacizumab Temozolomide Vorinostat High Grade Glioma Patient Pediatric High Grade Glioma 
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Conflict of interest

  The authors declare no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Pediatric Neuro-OncologyAnn and Robert H. Lurie Children’s Hospital of ChicagoChicagoUSA
  2. 2.Pediatric Oncology BranchNational Cancer InstituteBethesdaUSA

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