Journal of Neuro-Oncology

, Volume 113, Issue 1, pp 117–125 | Cite as

Surgical outcomes in choroid plexus papillomas: an institutional experience

  • Michael Safaee
  • Aaron J. Clark
  • Orin Bloch
  • Michael C. Oh
  • Anahat Singh
  • Kurtis I. Auguste
  • Nalin Gupta
  • Michael W. McDermott
  • Manish K. Aghi
  • Mitchel S. Berger
  • Andrew T. Parsa
Clinical Study


Choroid plexus papillomas (CPPs) are rare, indolent lesions that comprise less than 0.5 % of intracranial tumors. We sought to assess the long-term outcomes and associated surgical complications at our institution. A review of the University of California, San Francisco (UCSF) Brain Tumor Research Center (BTRC) database was performed to identify a cohort of patients treated for CPP from 1997 to 2011. Patients were grouped based on tumor location and extent of resection. Outcomes including progression-free survival and surgical complications were assessed. We identified 24 patients (16 female, 8 male) ranging in age from 6 months to 55 years (median 29 years) treated at our institution. Tumors were found in the following locations: 16 (67 %) fourth ventricle/cerebellopontine angle; 7 (29 %) lateral ventricle; 1 (4 %) third ventricle. Gross total resection (GTR) was achieved in 20 patients (83 %) with subtotal resection (STR) in 4 (17 %). Median follow-up time was 2.8 years with 3 recurrences identified at 1.6, 3.3, and 8.5 years. Extent of resection and tumor location were not associated with recurrence. There was one new permanent neurologic deficit detected after surgery. All patients were alive at most recent follow-up. Attempted gross total resection is the standard treatment for CPPs and generally associated with excellent outcomes. Since recurrences are rare, even among patients who undergo STR, radiation may be reserved for cases of tumor progression. This modern experience at a tertiary care center performed exclusively during the MRI-era demonstrates that CPPs can be safely removed with minimal morbidity and good tumor control.


Choroid plexus papilloma Surgical resection Complications Tumor recurrence 



Mr. Safaee was supported by a grant from the Doris Duke Charitable Foundation. Dr. Parsa was partially funded by the Reza and Georgianna Khatib Endowed Chair in Skull Base Tumor Surgery.

Conflict of interest

  The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Michael Safaee
    • 1
  • Aaron J. Clark
    • 1
  • Orin Bloch
    • 1
  • Michael C. Oh
    • 1
  • Anahat Singh
    • 1
  • Kurtis I. Auguste
    • 1
    • 2
  • Nalin Gupta
    • 1
    • 2
  • Michael W. McDermott
    • 1
  • Manish K. Aghi
    • 1
  • Mitchel S. Berger
    • 1
  • Andrew T. Parsa
    • 1
  1. 1.Department of Neurological SurgeryUniversity of California at San FranciscoSan FranciscoUSA
  2. 2.Department of PediatricsUniversity of California at San FranciscoSan FranciscoUSA

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