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Journal of Neuro-Oncology

, Volume 108, Issue 3, pp 513–519 | Cite as

FABP4 is a candidate marker of cerebellar liponeurocytomas

  • Elena Anghileri
  • Marica Eoli
  • Rosina Paterra
  • Paolo Ferroli
  • Bianca Pollo
  • Valeria Cuccarini
  • Emanuela Maderna
  • Giovanni Tringali
  • Marco Saini
  • Ettore Salsano
  • Gaetano Finocchiaro
Clinical Study

Abstract

Cerebellar liponeurocytoma (cLPN) is a very rare central nervous system (CNS) tumour recently recognized as a clinical and pathological entity distinct from medulloblastoma (MB), and included in the WHO classification of CNS tumours under the heading “glioneuronal tumours”. cLPN typically develop in adult age and have a favourable prognosis compared with MB. In this work, we reviewed the clinical and neuroradiological data of two novel cases of adult cLPN diagnosed at our institution; one patient developed distant metastases. We tried to identify novel molecular markers for this malignancy. We found that the transcription factor NEUROG1 (but not ATOH1) is expressed in cLPN, unlike normal adult cerebellum, and that fatty acid binding protein 4 (FABP4), typically found in adipocytes, is significantly overexpressed compared with both normal adult cerebellum and human MB. These findings suggest cLPN occur as a result of transformation of cerebellar progenitors, which are distinct from cerebellar granule progenitors, and aberrantly differentiate into adipocyte-like tumour cells. They also suggest that analysis of FABP4 expression is of help to differentiate cLPN from MB.

Keywords

Cerebellar liponeurocytoma FABP4 Medulloblastoma 

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Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Elena Anghileri
    • 1
  • Marica Eoli
    • 1
  • Rosina Paterra
    • 1
  • Paolo Ferroli
    • 2
  • Bianca Pollo
    • 3
  • Valeria Cuccarini
    • 4
  • Emanuela Maderna
    • 3
  • Giovanni Tringali
    • 2
  • Marco Saini
    • 2
  • Ettore Salsano
    • 1
  • Gaetano Finocchiaro
    • 1
  1. 1.Unit of Molecular Neuro-oncologyFondazione IRCCS C. BestaMilanItaly
  2. 2.Department of NeurosurgeryFondazione IRCCS C. BestaMilanItaly
  3. 3.Unit of NeuropathologyFondazione IRCCS C. BestaMilanItaly
  4. 4.Unit of NeuroradiologyFondazione IRCCS C. BestaMilanItaly

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