Journal of Neuro-Oncology

, Volume 108, Issue 2, pp 227–230 | Cite as

Refining endpoints in brain tumor clinical trials

  • Christina A. Meyers
  • Edwin P. Rock
  • Howard A. Fine
Methods and Clinical Tools for Outcome Assessments


As targeted therapies advance treatment for brain tumors, standard clinical trial endpoints of survival, progression free survival and radiographic response have become insufficient to capture clinical benefit. Brain cancer is a malignancy with neurodegenerative features. In this setting prolongation of life and/or radiographic stability are less clinically meaningful if neurocognitive function substantially declines. Hence evaluation of new therapeutic strategies should routinely include periodic assessment of neurocognitive function.


Brain cancer Clinical trials Neurocognitive function 


Conflict of interest statement

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Christina A. Meyers
    • 1
  • Edwin P. Rock
    • 2
  • Howard A. Fine
    • 3
  1. 1.Department of Neuro-OncologyM.D. Anderson Cancer CenterHoustonUSA
  2. 2.Otsuka Pharmaceutical Development and Commercialization IncRockvilleUSA
  3. 3.Neuro-Oncology BranchNational Cancer InstituteBethesdaUSA

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