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Primary intracranial leiomyosarcoma in an immunocompetent patient: case report

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Abstract

We report a case of intracranial leiomyosarcoma (LMS) arising after resection of neurofibroma at the cerebellopontine angle. A 45-year-old immunocompetent woman presented with recurrence of a tumor 9 years after resection performed in another hospital. Magnetic resonance imaging demonstrated a heterogeneously enhancing, dura-based mass at the left cerebellopontine angle. The tumor was subtotally removed via lateral suboccipital craniotomy. LMS was diagnosed based on histological and immunohistochemical findings. Postoperatively, although the patient was treated using local radiotherapy, she died due to rapid regrowth of the tumor. Reevaluation of the specimen obtained in the first operation led to a diagnosis of neurofibroma. Both LMS and neurofibroma rarely occur intracranially. LMS is generally thought to arise from smooth muscle cells of the blood vessels or pluripotent mesenchymal cells. In this case, LMS might also have originated from smooth muscle cells of the vessels in the neurofibroma, possibly associated with mechanical and/or heat stimulation during the previous surgery.

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Acknowledgement

The authors wish to thank Dr. Takanori Hirose of Tokushima Prefectural Central Hospital for offering the immunohistochemical photomicrograph of h-caldesmon.

Disclosure

The authors have no personal financial or institutional interest in any of the drugs, materials, or devices described in this article.

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Authors and Affiliations

  1. Department of Neurosurgery, Osaka Neurological Institute, 2-6-23 Shonai Takara-Machi, Toyonaka, Osaka, 561-0836, Japan

    Yasunori Fujimoto & Akatsuki Wakayama

  2. Department of Pathology, Gunma University Hospital, 3-39-15 Showa-Machi, Maebashi, Gunma, 371-8511, Japan

    Junko Hirato

  3. Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yasunori Fujimoto & Toshiki Yoshimine

Authors
  1. Yasunori Fujimoto
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  2. Junko Hirato
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  3. Akatsuki Wakayama
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  4. Toshiki Yoshimine
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Corresponding author

Correspondence to Yasunori Fujimoto.

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Fujimoto, Y., Hirato, J., Wakayama, A. et al. Primary intracranial leiomyosarcoma in an immunocompetent patient: case report. J Neurooncol 103, 785–790 (2011). https://doi.org/10.1007/s11060-010-0450-z

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  • DOI: https://doi.org/10.1007/s11060-010-0450-z

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