Journal of Neuro-Oncology

, Volume 100, Issue 2, pp 281–283 | Cite as

Treatment-induced leukoencephalopathy in primary CNS lymphoma presenting as lower body parkinsonism

  • Antonio Milia
  • Giuseppina Pilia
  • Maria Giuseppina Mascia
  • Francesco Maria Manconi
Case Report


Lower body parkinsonism (LBP) is a term coined to identify a relatively homogeneous subgroup of parkinsonism, distinct from idiopathic parkinson’s disease (PD) and characterized by gait difficulty with postural instability, freezing, lack of or minimal upper limb involvement, and poor response to levodopa. Although vascular etiology is highly predominant, LBP had been more rarely associated with other causes such as advanced PD and normal pressure hydrocephalus (NPH). We describe the case of a patient treated with chemoradiotherapy for a primary CNS lymphoma (PCNSL), who several years later presented a clinical picture strongly evocative of LBP. Neuroimaging studies showed diffuse subcortical white matter lesion suggesting radiotherapy-induced leukoencephalopathy. To our knowledge, this is the first case of clinically manifest LBP described in patients who received effective PCNSL therapy.

Case report

A 54-year-old woman, with no history of hypertension, was referred to...


Motor Symptom Primary Central Nervous System Lymphoma Postural Instability Normal Pressure Hydrocephalus Normal Pressure Hydrocephalus 
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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Antonio Milia
    • 1
  • Giuseppina Pilia
    • 1
  • Maria Giuseppina Mascia
    • 1
  • Francesco Maria Manconi
    • 1
  1. 1.UO Neurologia Riabilitativa Ospedale Santissima Trinità CagliariCagliariItaly

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