Glioblastoma in multiple sclerosis: a case report
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Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.
KeywordsGlioblastoma multiforme Multiple sclerosis Transcription factors Differential diagnosis
- 3.Paydarfar D, de la Monte SM (1997) Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12â€“1997. A 50-year-old woman with multiple sclerosis and an enlarging frontal-lobe mass. N Engl J Med 336:1163–1171. doi: 10.1056/NEJM199704173361608 PubMedCrossRefGoogle Scholar