Journal of Neuro-Oncology

, Volume 90, Issue 1, pp 117–124 | Cite as

RETRACTED ARTICLE: Applications of radiotherapy and radiosurgery in the management of pediatric Cushing’s disease: a review of the literature and our experience

  • Jay Jagannathan
  • Adam S. Kanter
  • Claire Olson
  • Jonathan H. Sherman
  • Edward R. LawsJr.
  • Jason P. Sheehan
clinical-patient studies


Surgical extirpation of pituitary adenomas is considered the mainstay of therapy in pediatric patients with Cushing’s disease. However, a small subset of patients will require adjuvant therapy either due to tumor invasiveness, or disease recurrence. Conventional radiation therapy (or radiotherapy) delivers ionizing radiation to control hormonally active cells in fractionated doses (spread out over time) in order to give normal cells time to recover, while radiosurgery involves focusing a high dose of radiation structures in a single treatment session to the adenoma while generally sparing the normal gland and surrounding of any substantial amount of radiation. This paper reviews the effectiveness of radiation in the treatment of pediatric Cushing’s disease.


Cushing’s disease Outcomes Radiation Pediatrics Pituitary Radiosurgery Surgery 


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Jay Jagannathan
    • 1
  • Adam S. Kanter
    • 2
  • Claire Olson
    • 1
  • Jonathan H. Sherman
    • 1
  • Edward R. LawsJr.
    • 3
  • Jason P. Sheehan
    • 1
  1. 1.Department of Neurological SurgeryUniversity of Virginia Health Sciences Center, University of VirginiaCharlottesvilleUSA
  2. 2.Department of NeurosurgeryUniversity of Pittsburgh Medical CenterPittsburghUSA
  3. 3.Department of NeurosurgeryStanford University Medical CenterStanfordUSA

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