Journal of Neuro-Oncology

, Volume 86, Issue 2, pp 225–229 | Cite as

Brain lymphoma: usefulness of the magnetic resonance spectroscopy

  • Sophie Taillibert
  • Rémy Guillevin
  • Carole Menuel
  • Marc Sanson
  • Khê Hoang-Xuan
  • Jacques Chiras
  • Hugues Duffau
Clinical-Patient Studies


The diagnosis of primary central nervous system lymphoma (PCNSL) should always be considered as an emergency because of the therapeutic consequences it implies. In immunocompetent patients, it relies on stereotactic biopsy. Unfortunately, clinical and radiological features may be misleading and delay the diagnostic procedure. The case we report here illustrates the contribution of magnetic resonance spectroscopy in the diagnostic approach of a very atypical PCNSL.


Demyelination Multiple sclerosis Magnetic resonance spectroscopy Primary CNS lymphoma 


  1. 1.
    Baehring JM et al (2003) Neurolymphomatosis. Neuro Oncol 5(2):104–115PubMedCrossRefGoogle Scholar
  2. 2.
    Beristain X, Azzarelli B (2002) The neurological masquerade of intravascular lymphomatosis. Arch Neurol 59(3):439–443PubMedCrossRefGoogle Scholar
  3. 3.
    Kim DG et al (1996) Primary central nervous system lymphoma: variety of clinical manifestations and survival. Acta Neurochir (Wien) 138(3):280–289CrossRefGoogle Scholar
  4. 4.
    Quinones-Hinojosa A et al (2000) Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature. J Neurosurg 92(1):165–169PubMedCrossRefGoogle Scholar
  5. 5.
    Shenkier TN (2005) Unusual variants of primary central nervous system lymphoma. Hematol Oncol Clin North Am 19(4):651–664, viGoogle Scholar
  6. 6.
    Singh A et al (1982) Steroid-induced remissions in CNS lymphoma. Neurology 32(11):1267–1271PubMedGoogle Scholar
  7. 7.
    Al-Yamany M et al (1999) Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology. J Neurooncol 42(2):151–159PubMedCrossRefGoogle Scholar
  8. 8.
    Kon T et al (2003) A primary CNS lymphoma in spontaneous remission for 3.5 years after initial detection of the lesions by MRI. Brain Tumor Pathol 20(1):27–31PubMedCrossRefGoogle Scholar
  9. 9.
    Rubin M et al (1987) Spontaneous temporary remission in primary CNS lymphoma. Can J Neurol Sci 14(2):175–177PubMedGoogle Scholar
  10. 10.
    DeAngelis LM et al (1990) Primary CNS lymphoma: combined treatment with chemotherapy and radiotherapy. Neurology 40(1):80–86PubMedGoogle Scholar
  11. 11.
    DeAngelis LM (1990) Primary central nervous system lymphoma imitates multiple sclerosis. J Neurooncol 9(2):177–181PubMedCrossRefGoogle Scholar
  12. 12.
    Lucchinetti C et al (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47(6):707–717PubMedCrossRefGoogle Scholar
  13. 13.
    Lach B, Atack E, Hylton D (1985) Clinical and pathological analysis of primary lymphomas of the brain: association of tumors with demyelinative leukoencephalopathy. Neuropathology Exp Neurol 44(309)Google Scholar
  14. 14.
    Murphy JK, O’Brien CJ, Ironside JW (1989) Morphologic and immunophenotypic characterization of primary brain lymphomas using paraffin-embedded tissue. Histopathology 15(5):449–460PubMedCrossRefGoogle Scholar
  15. 15.
    Ducreux D et al (2003) Diffusion-weighted imaging and single-voxel MR spectroscopy in a case of malignant cerebral lymphoma. Neuroradiology 45(12):865–868PubMedCrossRefGoogle Scholar
  16. 16.
    Moller-Hartmann W et al (2002) Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology 44(5):371–381PubMedCrossRefGoogle Scholar
  17. 17.
    Hsu EW, Aiken NR, Blackband SJ (1996) Nuclear magnetic resonance microscopy of single neurons under hypotonic perturbation. Am J Physiol 271(6 Pt 1):C1895–C1900PubMedGoogle Scholar
  18. 18.
    Nelson SJ et al (2002) In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging 16(4):464–476PubMedCrossRefGoogle Scholar
  19. 19.
    Harting I et al (2003) Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy. Neurosci Lett 342(3):163–166PubMedCrossRefGoogle Scholar
  20. 20.
    Buhring U et al (2001) MRI features of primary central nervous system lymphomas at presentation. Neurology 57(3):393–396PubMedGoogle Scholar
  21. 21.
    Kuhlmann T et al (2001) Diagnosis of a multifocal B cell lymphoma with preceding demyelinating central nervous system lesions by single voxel proton MR spectroscopy. J Neurol Neurosurg Psychiatry 70(2):259–262PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Sophie Taillibert
    • 1
  • Rémy Guillevin
    • 2
    • 3
  • Carole Menuel
    • 2
  • Marc Sanson
    • 1
  • Khê Hoang-Xuan
    • 1
  • Jacques Chiras
    • 2
  • Hugues Duffau
    • 4
  1. 1.Department of Neuro-oncologyPitié Salpêtrière HospitalParisFrance
  2. 2.Department of NeuroradiologyPitié Salpêtrière HospitalParisFrance
  3. 3.Laboratoire d’imagerie fonctionnelle, INSERM U678Paris-6 UniversityParisFrance
  4. 4.Department of NeurosurgeryGui de Chauliac HospitalMontpellierFrance

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