Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines
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The transplantation of progenitor cells is a promising new approach for the treatment of gliomas. Marrow stromal cells (MSC) are possible candidates for such a cell-based therapy, since they are readily and autologously available and show an extensive tropism to gliomas in vitro and in vivo. However, the signals that guide the MSC are still poorly understood. In this study, we show that gliomas have the capacity to actively attract MSC by secreting a multitude of angiogenic cytokines. We demonstrate that interleukin-8 (IL-8), transforming growth factor-ß1 (TGF-ß1) and neurotrophin-3 (NT-3) contribute to this glioma-directed tropism of human MSC. Together with the finding that vascular endothelial growth factor (VEGF) is another MSC-attracting factor secreted by glioma cells, these data support the hypothesis that gliomas use their angiogenic pathways to recruit mesenchymal progenitor cells.
KeywordsAngiogenesis Glioma Interleukin-8 Marrow stromal cells Migration Neurotrophin-3 Transforming growth factor-ß1
This work was supported by grants of the Förderprogramm für Forschung und Lehre, LMU Munich, Germany, and by grants of the Friedrich-Baur-Stiftung, Munich, Germany. Parts of this work are elements of one co-author´s dissertation (Julia Roider) presented to the Medical Faculty, LMU Munich, Germany.
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