Journal of Neuro-Oncology

, Volume 83, Issue 1, pp 81–83 | Cite as

Marantic endocarditis (NBTE) with systemic emboli and paraneoplastic cerebellar degeneration: uncommon presentation of ovarian cancer

Clinical–Patient Studies


We report a case in which the only presenting symptoms of the underlying ovarian malignancy were that of paraneoplastic cerebellar degeneration and nonbacterial thrombotic endocarditis. If suspecting paraneoplastic cerebellar degeneration and nonbacterial thrombotic endocarditis, complete physical examination, including pelvic exams in female patients is warranted. Investigations should include CT chest/abdominal/pelvis, MRI brain, and Transesophageal Echocardiogram. Early recognition will lead to early diagnosis of occult malignancy and initiation of appropriate therapy. Awareness of these complications as initial presentation for internists, gynecologists and neurologists may avoid diagnostic delay.


Nonbacterial thrombotic endocarditis Paraneoplastic cerebellar degeneration Ovarian cancer Marantic endocarditis Paraneoplastic syndrome 



Paraneoplastic cerebellar degeneration


Non-bacterial thrombotic endocarditis


Emergency room


Magnetic resonance imaging


Transesophageal echocardiogram


Computed tomography


Cerebrospinal fluid


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Internal Medicine/Hematology–OncologyEvanston Northwestern HealthcareEvanstonUSA

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