Journal of Neuro-Oncology

, Volume 81, Issue 2, pp 167–174 | Cite as

The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas

  • Narendra Nathoo
  • Kene Ugokwe
  • Albert S. Chang
  • Liang Li
  • Jeffrey Ross
  • John H. Suh
  • Michael A. Vogelbaum
  • Gene H. Barnett
Clinical - patient studies



Meningiomas are common brain tumors with somatostatin receptors that bind octreotide. We report the use of 111indium-octreotide brain scintigraphy (OBS) for the non-invasive differentiation of meningiomas from other cranial dural-based pathology.


A retrospective analysis of our experience with OBS for non-invasive identification of meningiomas was performed. Two neuroradiologists, blinded to clinical data, utilized a standardized grading scheme to define the uptake of octreotide at 6 and 24 h post-administration. The correlation between (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET), magnetic resonance imaging (MRI) scans, and octreotide uptake was assessed.


The cohort consisted of 50 patients having a mean age of 62.4 years and a median follow-up time of 24 months. Management consisted of biopsy (n = 4); resection (n = 10); observation (n = 16); radiosurgery (n = 21); and external beam radiotherapy (n = 3). OBS was correlated with MRI (n = 50); FDG-PET brain studies (n = 38); histology (n = 14), and angiography (n = 1). In cases where definitive diagnosis could be made, the sensitivity, specificity, positive and negative predictor values for OBS alone were 100; 50; 75; and 100, respectively. OBS provided false positive data in 3 patients (metastasis, chronic inflammation, lymphoma). Use of OBS with MRI to differentiate meningiomas from other lesions was highly significant (P < 0.001). FDG-PET correctly identified malignant pathology with 100% sensitivity and specificity.


OBS may increase the diagnostic specificity of conventional MRI when differentiating meningioma from other dural-based pathologies, while the addition of FDG-PET differentiates benign from malignant lesions.


Brain Dura Meningioma Octreotide Scintigraphy FDG-PET 


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We thank Ms. Christine Moore, CME Department of Neurosurgery, Cleveland Clinic Foundation, for her assistance with the preparation of this manuscript.


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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Narendra Nathoo
    • 1
    • 5
  • Kene Ugokwe
    • 1
    • 5
  • Albert S. Chang
    • 2
  • Liang Li
    • 3
  • Jeffrey Ross
    • 2
    • 5
  • John H. Suh
    • 4
    • 5
  • Michael A. Vogelbaum
    • 1
    • 5
  • Gene H. Barnett
    • 1
    • 5
  1. 1.Department of NeurosurgeryThe Taussig Cancer Center, The Cleveland Clinic FoundationClevelandUSA
  2. 2.Department of NeuroradiologyThe Taussig Cancer Center, The Cleveland Clinic FoundationClevelandUSA
  3. 3.Department of Biostatistics and EpidemiologyThe Taussig Cancer Center, The Cleveland Clinic FoundationClevelandUSA
  4. 4.Department of Radiation OncologyThe Taussig Cancer Center, The Cleveland Clinic FoundationClevelandUSA
  5. 5.Brain Tumor InstituteThe Taussig Cancer Center, The Cleveland Clinic FoundationClevelandUSA

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