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Journal of Neuro-Oncology

, Volume 80, Issue 1, pp 57–61 | Cite as

Complications of a temozolomide overdose: a case report

  • Alexander M. Spence
  • Hans-Peter Kiem
  • Sonia Partap
  • Scott Schuetze
  • John R. Silber
  • Richard A. Peterson
Clinical–Patient Studies

Abstract

Purpose and background

This is a report of a 53 year-old man with a glioblastoma multiforme (GBM) treated with an excessive dose of temozolomide (TMZ).

Methods

This is a single case review of all clinically relevant records. O 6-methylguanine-DNA methyltransferase activity was determined by a biochemical assay.

Results

Following conventional radiotherapy (RT) without concurrent chemotherapy, the patient received 5,500 mg of TMZ over 2 days. At the standard dose of 200 mg/m2/day his total 5-day dose should have been 1,940 mg. Acutely he had nausea, vomiting and diarrhea for 2 days which cleared. The dominant severe toxicity was pancytopenia between one and four weeks after TMZ which was complicated by secondary infections that were successfully managed. Transient transaminitis occurred but there were no significant pulmonary, renal or other systemic toxicities. His progression free survival was 22 months and overall survival 24 months.

Conclusion

His outcome suggests that TMZ may prove to be a good agent for dose-escalation trials with hematopoietic stem cell rescue.

Keywords

Glioblastoma multiforme Temozolomide Overdose Toxicity 

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Alexander M. Spence
    • 1
  • Hans-Peter Kiem
    • 2
  • Sonia Partap
    • 1
  • Scott Schuetze
    • 2
  • John R. Silber
    • 3
  • Richard A. Peterson
    • 1
  1. 1.Department of NeurologyUniversity of Washington School of MedicineSeattleUSA
  2. 2.Department of Medicine (Medical Oncology)University of Washington School of MedicineSeattleUSA
  3. 3.Department of NeurosurgeryUniversity of Washington School of MedicineSeattleUSA

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