Summary
Intracranial germinoma arising primarily in the midbrain is extremely rare. We present the first reported case of cystic midbrain germinoma that lacked evident solid components and mimicked a midbrain glioma. In a 22-year-old man with headache and diplopia, magnetic resonance imaging showed a ring-enhancing lesion in the midbrain. The preoperative diagnosis included brain stem glioma, metastasis, and neuroepithelial cyst. A neuroendoscopic biopsy specimen provided a histologic diagnosis of germinoma. The patient responded well to chemotherapy and radiotherapy. The case illustrates the diagnostic value of neuroendoscopic biopsy in the differential diagnosis of brainstem lesions in adult. The possibilities considered should now include germinoma.
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Amor SB, Siddiqui K, Baessa S: Primary midbrain germinoma Br J Neurosurg 18: 310–313, 2004
Matsumoto K, Tabuchi A, Tamesa N, Nakashima H, Ohmoto T: Primary intracranial germinoma involving the midbrain Clini Neurol Neurosurg 100:292–295, 1998
Uchino M, Nemoto M, Ohtsuka T, Seiki Y, Shibata I: Extraneural metastasis of pineal germinoma through a Ventriculoperitoneal Shunt Following histological change: No Shinkei Geka 27:269–274, 1999 [Article in Japanese with English abstract]
Higano S, Takahashi S, Ishi K, Matsumoto K, Ikeda H, Sakamoto K Germinoma originating in the basal ganglia and thalamus: MR and CT evaluation AJNR 15:1435–1441, 1994
Kim DI, Yoon PH, Ryu YH, Jeon P, Hwang GJ MRI of germinomas arising from the basal ganglia and thalamus Neuroradiology 40:507–511, 1998
Moon WK, Chang KH, Kim IO, Han MH, Choi CG, Suh DC, Yoo SJ, Han MC Germinomas of the basal ganglia and thalamus: MR findings and a comparison between MR, CT AJR 162:1413–1417, 1994
Soejima T, Takeshita I, Yamamoto H, Tsukamoto Y, Fukui M, Matsuoka S Computed tomography of germinoma in basal ganglia and thalamus Neuroradiology 29:366–370, 1987
Sun B, Wang CC, Wang J: MRI characteristics of midbrain tumours Neuroradiology 41:158–162, 1999
Mizoguchi M, Inamura T, Hikita T, Cheng CL, Ohgami S Neuroendoscopic biopsy of tectal glioma: case report Minim Invas Neurosurg 43:53–55, 2000
Nishikawa T, Kang Y, Lee T, Takehira N, Waga S: Application of endoscopy for a midbrain tumor Minim Invas Neurosurg 46:182–185, 2003
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Uchino, M., Haga, D., Mito, T. et al. Primary midbrain cystic germinoma mimicking glioma: a case with neuroendoscopic biopsy. J Neurooncol 79, 255–258 (2006). https://doi.org/10.1007/s11060-006-9138-9
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DOI: https://doi.org/10.1007/s11060-006-9138-9