Early Life Stress: Consequences for the Development of the Brain
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This literature review demonstrates the importance and consequences of early life stress for the development of the brain and its role in the formation of neurological and mental illnesses (particularly depression). The most dangerous is chronic early life stress during the neonatal period of development in the first days after birth, when the effects on the development of the brain, neuro-, synapto-, and glio-, and angiogenesis are the most stable. Among all the neuropsychological effects of early life stress, the most common are apparent as depressive disorders in humans and animals, and this constitutes a widely used model of experimental depression in rodents.
Keywordsearly life stress animal models depression neurogenesis angiogenesis
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- Baek, S. B., Bahn, G., Moon, S. J., et al., “The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups,” Neurosci. Lett., 488, No. 1, 26–30 (2011).CrossRefPubMedGoogle Scholar
- Gunn, B. G., Cunningham, L., Cooper, M. A., et al., “Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response,” J. Neurosci., 33, No. 50: 19534–19554 (2013).CrossRefPubMedPubMedCentralGoogle Scholar
- Jasarevic, E., Rodgers, A. B., and Bale, T. L., “A novel role for maternal stress and microbial transmission in early life programming and neurodevelopment,” Neurobiol. Stress, No. 1, 81–88 (2015).Google Scholar
- Krivoruchenko, V. K., “Child abuse: occurrence and prevention,” www.zpu-journal.ru/e-zpu/2012/3/Krivoruchenko_Child-Abuse/ (2012), acc. Feb. 2, 2016.
- Lajud, N., Roque, A., Cajero, M., et al., “Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood,” Psychoneuroendocrinology, 37, No. 3, 410–420 (2012).CrossRefPubMedGoogle Scholar
- Lewis, A. J., Galbally, M., Gannon, T., and Symeonides, C., “Early life programming as a target for prevention of child and adolescent mental disorders,” BMC Med., 12, 33: 1–15 (2014).Google Scholar
- Loi, M., Koricka, S., Lucassen, P. J., and Joels, M., “Age- and sex-dependent effects of early life stress on hippocampal neurogenesis,” Front. Endocrinol. (Lausanne), 5, 1–11 (2014).Google Scholar
- Migunova, Yu. V., “Abuse of children in families as a subject of sociological analysis,” Current Problems in Science and Edu cation, www.science-education.ru/Russia/article/view?id=12905, acc. Feb. 10, 2016.
- Moriceau, S., Shionoya, K., Jakubs, K., and Sullivan, R. M., “Early-life stress disrupts attachment learning: the role of amygdala corticosterone, locus ceruleus corticotropin releasing hormone, and olfactory bulb norepinephrine,” J. Neurosci., 29, No. 50: 15745–15755 (2009).CrossRefPubMedPubMedCentralGoogle Scholar
- Numbers of Minors Falling Victim to Criminal Assault, Federal State Statistics Service (Rosstat) (2000–2013), www.science-education.ru/Russia/article/view?id=12905, acc. Feb. 10, 2016.
- Oomen, C. A., Soeters, H., Audureau, N., et al., “Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood,” J. Neurosci., 30, No. 19, 6635–6645 (2010).CrossRefPubMedGoogle Scholar
- Raineki, C., Cortés, M. R., Belnoue, L., and Sullivan, R. M., “Effects of early-life abuse differ across development: infant social behavior deficits are followed by adolescent depressive-like behaviors mediated by the amygdala,” J. Neurosci., 32, No. 22: 7758–7765 (2012).CrossRefPubMedPubMedCentralGoogle Scholar
- Salmina, A. B., Komleva, Yu. K., Kuvacheva, N. V., et al., “Molecular mechanisms of impairments to the development of the brain in preand neonatal period,” Vopr. Sovrem. Ped., No. 6, 15–20 (2012).Google Scholar
- Tarry-Adkins, J. L. and Ozanne, S. E., “Mechanisms of early life programming: current knowledge and future directions,” Am. J. Clin. Nutr., 94, No. 6, Supplement, 1765S–1771S (2011).Google Scholar
- Yauzina, N. A., Cherepanov, S. M., Komleva, Yu. K., et al., “The effects of early life stress on behavior, neurogenesis, and apoptosis of brain cells in rats,” Sib. Med. Obozr., No. 5, 3–10 (2013b).Google Scholar
- Yauzina, N. A., Komleva, Yu. K., Salmina, A. B., et al., “Current experimental models of depression,” Biomeditsina, No. 1, 61–71 (2013a).Google Scholar