Effects of Melatonin on the Interaction between the Level of Accumulation of Oxidatively Modified Proteins, the Activity of Antioxidant Enzymes, and the State of Proteolysis in the Basal Ganglia of the Brain in Acute Hypoxia

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The effects of melatonin on the interaction between the level of accumulation of oxidatively modified proteins, the activity of antioxidant enzymes, and the state of the proteolysis system in the basal ganglia (caudate nucleus, globus pallidus, nucleus accumbens, amygdaloid complex) of the brain were studied in conditions of acute hypoxia. Acute hypoxia was found to increase protein peroxidation and proteolysis intensity in the basal ganglia, and also to decrease the activity of antioxidant defense enzymes. Administration of melatonin (1 mg/kg) before modeling of acute hypoxia was accompanied by a decrease in the content of protein peroxidation products, an increase in the activity of the antioxidant enzymes, and normalization of the intensity of proteolysis.

Keywords

melatonin oxidatively modified proteins antioxidant defense enzymes proteolysis basal ganglia acute hypoxia 

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Bukovina State Medical UniversityChernovtsyUkraine

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