Neuroscience and Behavioral Physiology

, Volume 48, Issue 2, pp 174–179 | Cite as

Effects of Stimulation of the Dopaminergic System of the Brain on Food Preference in Rats


Experiments in rats addressing searching behavior in a maze with symmetrical reinforcement demonstrated an effect consisting of preference for food presented in a particular form. The dopaminergic system of the brain was shown to have an important role in forming reinforcement preference when the sensory properties of the food presented to the experiment animals changed. The possibility of using this type of discrete reinforcement as an experimental model for studies of the physiological mechanisms of addiction, which is directly related to food preference, as well as various forms of pathological dependence seen on consumption of pharmacological agents, was assessed.


feeding behavior discrete reinforcement food preference motivation dopamine rats 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S. V. Al’bertin, “Involvement of the DA-reactive system of the caudate nucleus in regulating operant conditioned reflexes of different levels of complexity,” Fiziol. Zh. SSSR, 71, 87–94 (1985).PubMedGoogle Scholar
  2. 2.
    S. V. Al’bertin, “Involvement of the nucleus accumbens in forming spatial selection reactions in rats in a radial maze,” Ros. Fiziol. Zh., 88, No. 5, 545–552 (2002).Google Scholar
  3. 3.
    S. V. Al’bertin, Patent No. 2269295g RF, “A method for the diagnosis of attention deficit syndrome in animal experiments,” Byull. Izobret. Polezn. Modeli, No. 4 (2006).Google Scholar
  4. 4.
    S. V. Al’bertin, Patent No. 2520154g RF, “An apparatus for studying feeding behavior in animal experiments,” Byull. Izobret. Polezn. Modeli, No. 11 (2014).Google Scholar
  5. 5.
    S. V. Al’bertin, “A method for testing food preference in animal experiments,” Ros. Fiziol. Zh., 101, No. 10, 1128–1134 (2015).Google Scholar
  6. 6.
    O. S. Vinogradova, The Hippocampus and Memory, Nauka, Moscow (1975).Google Scholar
  7. 7.
    S. V. Albertin, A. B. Mulder, E. Tabuchi, et al, “Lesions of the medial shell of the nucleus accumbens impair rats in finding larger rewards but spare reward-seeking behavior,” Behav. Brain Res., 117, 173–183 (2000).CrossRefPubMedGoogle Scholar
  8. 8.
    S. V. Albertin and S. I. Wiener, “Neuronal activity in the nucleus accumbens and hippocampus in rats during formation of seeking behavior in radial maze,” Bull. Exp. Biol. Med., 158, No. 4, 405–409 (2015).CrossRefPubMedGoogle Scholar
  9. 9.
    A. M. Dossat, N. Lilly, K. Kay, and D. L. Williams, “Glucagon-like peptide receptors in nucleus accumbens affect food Intake,” J. Neurosci., 31, No. 41, 14453–14457 (2011).CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    D. M. Eagle, T. Humby, M. Howman, et al., “Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats,” Psychobiology, 27, No. 2, 267–276 (1999).Google Scholar
  11. 11.
    H. J. Groenewegen, A. B. Mulder, and A. V. L. Beijer, “Hippocampal and amygdaloid interactions in the nucleus accumbens,” Psychobiology., 27, No. 2, 149–164 (1999).Google Scholar
  12. 12.
    E. W. Holman, “Immediate and delayed reinforcers for flavor preferences in rats,” Learn. Motivat., 6, 91–100 (1975).CrossRefGoogle Scholar
  13. 13.
    S. H. Hulse and S. Sutter, “One drop licking in rats,” J. Compar. Physiol. Psychol., 66, No. 2, 536–539 (1968).CrossRefGoogle Scholar
  14. 14.
    M. Lyon and T. Robbins, “An action of central nervous system stimulant drugs: a general theory concerning amphetamine effects,” Curr. Dev. Psychopharmacology, 2, 79–163 (1975).Google Scholar
  15. 15.
    G. P. Mark, S. E. Smith, P. V. Rada, and B. G. Hoebel, “An appetitively conditioned taste elicits a preferential increase in mesolimbic dopamine release,” Pharmacol. Biochem. Behav., 48, 651–660 (1994).CrossRefPubMedGoogle Scholar
  16. 16.
    A. N. M. Schoffelmeer, B. Drukarch, T. J. De Vries, et al., “Insulin modulates cocaine sensitive monoamine transporter function and impulsive behavior,” J. Neurosci., 31, No. 4, 1284–1291 (2011).CrossRefPubMedGoogle Scholar
  17. 17.
    A. Sclafani, K. Touzani, and R. J. Bodnar, “Dopamine and learned food preference,” Physiol. Behav., 104, 64–68 (2011).CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    T. Sharp, T. Zetterstrom, T. Ljundberg, and V. Ungerstedt, “A direct comparison of amphetamine-induced behaviors and regional brain dopamine release in the rat using intracerebral dialysis,” Brain Res., 401, 322–330 (1987).CrossRefPubMedGoogle Scholar
  19. 19.
    S. I. Wiener, R. Shibata, E. Tabichi, et al., “Spatial and behavioral cor relates in nucleus accumbens neurons in zones receiving hippocampal or prefrontal cortical inputs,” Int. Congr. Ser. Amsterdam Excerpta Med., 1250, 275–292 (2003).CrossRefGoogle Scholar
  20. 20.
    I. Q. Whishaw, S. D. Oddie, R. K. McNamara, et al., “Psychophysiological methods for study of sensory-motor behavior using a food-carrying (hoarding) task in rodents,” J. Neurosci. Meth., 32, 123–133 (1990).CrossRefGoogle Scholar
  21. 21.
    S. C. Woods, R. J. Seeley, D. J. Baskin, and W. D. Schwarz, “Signals that regulate food intake and energy homeostasis,” Science, 280, No. 5368, 1378–1383 (1998).CrossRefPubMedGoogle Scholar
  22. 22.
    T. Zetterstrom, T. Sharp, C. A. Marsden, and V. Ungerstedt, “In vivo measurement of dopamine and its metabolites by intracerebral dialysis: change after d-amphetamine,” J. Neurochem., 41, 1769–1773 (1983).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pavlov Institute of Physiology, Russian Academy of SciencesSt. PetersburgRussia

Personalised recommendations