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Neuroscience and Behavioral Physiology

, Volume 46, Issue 9, pp 1024–1030 | Cite as

Latencies of the Sensory and Cognitive Components of Event-Related Potentials on Perception of Verbal Stimuli in Health and Schizophrenia

  • V. B. Strelets
  • A. Yu. Arkhipov
  • Zh. V. Garakh
Article
  • 35 Downloads

We report here studies of the early and later stages of cerebral information processes during passive reading of concrete words in healthy subjects and patients with schizophrenia using an event-related brain potentials method. Comparative analysis of the P100, N170, P200, and P300 components in the implicit situation showed that the latencies of the early components P100 and N170 were shorter in schizophrenia patients, while the latencies of the later P200 and P300 components were longer than those in healthy subjects. This suggests that schizophrenia involves a deficit in automated sensory processing of the stimulus, apparent as a shorter latency for the sensory components of the event-related potential, with the result that sensory analysis of the stimulus was incomplete and imprecise. The negative correlations between the latencies of the P100 and P200 components (“recognition potentials”) detected here in healthy subjects supported the hypothesis that the longer-lasting sensory processing of verbal stimuli shortens the time taken for its recognition. In schizophrenia patients, the ratio of the durations of the sensory and cognitive components of the event-related potential was impaired. A positive correlation was found between measures of the early and late components of potentials, perhaps because of the presence of nonsensory elements in the structure of the early components of event-related potentials.

Keywords

event-related potentials P100 N170 P200 P300 schizophrenia concrete words latency 

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References

  1. Bentin, S., Mouchetant-Rostsing, Y., Giard, et al., “ERP manifestations of processing printed words at different psycholinguistic levels: time course and scalp distribution,” J. Cogn. Neurosci., 11, 235–260 (1999).Google Scholar
  2. Bramon, E., Rabe-Hesketh, S., Sham, P., and Murray, R. M., “Meta-analysis of the P300 and P50 waveforms in schizophrenia,” Schizophr. Res, 70, 315–329 (2004).CrossRefPubMedGoogle Scholar
  3. Butler, P. D. and Javitt, D. C., “Early-stage visual processing deficits in schizophrenia,” Curr. Opin. Psychiatry, 18, No. 2, 151–157 (2005).CrossRefPubMedPubMedCentralGoogle Scholar
  4. Calderone, D. J., Hoptman, M. J., Martínez, A., et al., “Contributions of low and high spatial frequency processing to impaired object recognition circuitry in schizophrenia,” Cereb. Cortex, 23, No. 8, 1849–1858 (2013).CrossRefPubMedGoogle Scholar
  5. Cohen, L., Dehaene, S., Vinckier, F., et al., “Reading normal and degraded words: contribution of the dorsal and ventral visual pathways,” Neuroimage, 40, No. 1, 353–366 (2008).Google Scholar
  6. Crow, T. J., “How and why genetic linkage has not solved the problem of psychosis: review and hypothesis,” Am. J. Psychiatry, 164, 13–21 (2007).CrossRefPubMedGoogle Scholar
  7. Dien, J., “The neurocognitive basis of reading single words as seen through early latency ERPs: A model of converging pathways,” Biol. Psychol., 80, No. 1, 10–22 (2009).CrossRefPubMedGoogle Scholar
  8. Fellinger, R., Klimesch, W., Schnakers, C., et al., “Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses,” Clin. Neurophysiol., 122, No. 11, 2177–2184 (2011).CrossRefPubMedGoogle Scholar
  9. Ford, J., “Schizophrenia: The broken P300 and beyond,” Psychophysiology, 36, No. 6, 667–682 (1999).Google Scholar
  10. González-Hernández, J. A, Pita-Alcorta, C., Padrón, A., et al., “Basic visual dysfunction allows classification of patients with schizophrenia with exceptional accuracy,” Schizophr. Res., 159, 226–233 (2014).CrossRefPubMedGoogle Scholar
  11. Gorakh Zh. V., Yukhnenko, D. V., and Strelets, V. B. “Sensory analysis of words of with different occurrence frequencies in health and patients with schizophrenia and schizophrenic spectrum disorders,” Zh. Vyssh. Nerv. Deyat., 64, No. 4, 376–387 (2014).Google Scholar
  12. Hauk, O., Davis, M. H., Ford, M., et al., “The time course of visual word-recognition as revealed by linear regression analysis of ERP data,” Neuroimage, 30, No. 4, 1383–1400 (2006).Google Scholar
  13. Huang, M.-W., Chou, F. H.-C., Lo, P.-Yu., and Cheng, K.-S., “A comparative study on long-term evoked auditory and visual potential responses between schizophrenic patients and normal subjects,” BMC Psychiatry, 11, 74–82 (2011).CrossRefPubMedPubMedCentralGoogle Scholar
  14. Ivanitskii, A. M., Strelets, V. B., and Korsakov, I. A., Information Processes and Mental Activity, Nauka, Moscow (1984).Google Scholar
  15. Jeon, Y. W. and Polich, J., “Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications,” Psychophysiology, 40, No. 5, 684–701 (2003).Google Scholar
  16. Koyama, S., Hokama, H., Miyatani, M., et al., “ERP’s in schizophrenic patients during word recognition task and reaction times,” Electroencephalogr. Clin. Neurophysiol., 92, 546–554 (1994).CrossRefPubMedGoogle Scholar
  17. Lee, S. H., Kim, E. Y., Kim, S. R., et al., “Facial affect perception and event-related potential N170 in schizophrenia: A preliminary study,” Clin. Psychopharmacol. Neurosci., 5, 76–80 (2007).Google Scholar
  18. Lobier, M., Peyrin, C., Le Bas, J.-F., and Valdois, S., “Pre-orthographic character string processing and parietal cortex: A role for visual attention in reading?” Neuropsychologia, 50, 2195–2204 (2012).CrossRefPubMedGoogle Scholar
  19. Mar’ina, I. V., Strelets, V. B., Garakh Zh. V., et al., “Analysis of event-related brain potentials to verbal stimuli in health and schizophrenia,” Zh. Vyssh. Nerv. Deyat., 62, No. 2, 157–164 (2012).Google Scholar
  20. Martínez, A., Revheim, N., Butler, P. D., et al., “Impaired magnocellular/dorsal stream activation predicts impaired reading ability in schizophrenia,” NeuroImage: Clinical, 2, 8–16 (2013).CrossRefGoogle Scholar
  21. Minzenberg, M. J., Ober, B. A., and Vinogradov, S., “Semantic priming in schizophrenia: a review and synthesis,” J. Int. Neuropsychol. Soc., 8, No. 5, 699–720 (2002).CrossRefPubMedGoogle Scholar
  22. Missonnier, P., Herrmann, F. R., Zanello, A., et al., “Event-related potentials and changes of brain rhythm oscillations during working memory activation in patients with first-episode psychosis,” J. Psychiatry Neurosci., 37, No. 2, 95–105 (2012).CrossRefPubMedPubMedCentralGoogle Scholar
  23. Neuhaus, A. H., Karl, C., Hahn, E., et al., “Dissection of early bottom-up and top-down deficits during visual attention in schizophrenia,” Clin. Neurophysiol., 122, 90–98 (2011).CrossRefPubMedGoogle Scholar
  24. Petterson-Yeo, W., Allen, P., Benetti, S., et al., “Dysconnectivity in schizophrenia: Where are we now?” Neurosci. Biobehav. Rev., 35, 1110–1124 (2011).CrossRefGoogle Scholar
  25. Revheim, N., Butler, E. D., Schechter I., et al., “Reading impairment and visual processing defi cits in schizophrenia,” Schizophr. Res., 87, No. 1–3, 238–245 (2006).CrossRefPubMedPubMedCentralGoogle Scholar
  26. Rudell, A. P. and Hu, B., “Effect of long-time reading experience on reaction time and recognition potential,” Int. J. Psychophysiol., 76, No. 3, 158–168 (2010).CrossRefPubMedPubMedCentralGoogle Scholar
  27. Rudell, A. P. and Hua, J., “The recognition potential, word difficulty, and individual reading ability: on using event-related potentials to study perception,” J. Exp. Psychol. Hum. Percept. Perform., 23, 1170–1195 (1997).CrossRefPubMedGoogle Scholar
  28. Silverstein, S. M. and Keane, B. P., “Perceptual organization impairment in schizophrenia and associated brain mechanisms: review of research from 2005 to 2010,” Schizophr. Bull., 37, No. 4, 690–699 (2011).CrossRefPubMedPubMedCentralGoogle Scholar
  29. Stephan, K. E., Friston, K. J., and Frith, C. D., “Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Selfmonitoring,” Schizophr. Bull., 35, No. 3, 209–527 (2009).CrossRefGoogle Scholar
  30. Strelets, V. B., Gorakh, Zh. V., Mar’ina, I. V., et al., “The time characteristics of the initial stage of processing verbal information in health and schizophrenia,” Zh. Vyssh. Nerv. Deyat., 62, No. 2, 165–173 (2012).Google Scholar
  31. Tanaka, S., Maezawa, Y., and Kirino, E., “Classification of schizophrenia patients and healthy controls using P100 event-related potentials for visual processing,” Neuropsychobiology, 68, 71–78 (2013).CrossRefPubMedGoogle Scholar
  32. Uhlhaas, P. J., Haenschel, C., Nicolic, D., and Singer, W., “The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia,” Schizophr. Bull., 34, No. 5, 927–943 (2008).CrossRefPubMedPubMedCentralGoogle Scholar
  33. Vinckier, F., Cohen, L., Oppenheim, C., et al., “Reading impairment in schizophrenia: Disconnectivity within the visual system,” Neuropsychologia, 53, 187–196 (2014).CrossRefPubMedGoogle Scholar
  34. Vinckier, F., Naccache, L., Papeix, C., et al., “‘What’ and ‘where’ in word reading: Ventral coding of written words revealed by parietal atrophy,” J. Cogn. Neurosci., 18, 1998–2012 (2006).CrossRefPubMedGoogle Scholar
  35. Vinckier, F., Qiao, E., Pallier, C., et al., “The impact of letter spacing on reading: a test of the bigram coding hypothesis,” J. Vis., 11, No. 6, 1–21 (2011).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • V. B. Strelets
    • 1
  • A. Yu. Arkhipov
    • 1
  • Zh. V. Garakh
    • 1
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia

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