Neuroscience and Behavioral Physiology

, Volume 46, Issue 8, pp 895–902 | Cite as

Effects of Stimulation of the Hypothalamic Nuclei on Neurons in the Inferior Vestibular Nucleus after Prolonged Vibration and Administration of Proline-Rich Peptide 1

  • S. G. Sarkisyan
  • V. A. Chavushyan
  • V. S. Kamenetskii
  • S. M. Minasyan
  • K. V. Melkumyan
  • J. S. Sarkisyan

Impairments to vestibular function after exposure to vibration are to a significant extent due to adaptive-adjustment changes in neurotransmitter processes, which can be regulated by endogenous factors, particularly hypothalamic proline-rich peptide. Studies in Albino rats addressed the synaptic activity of individual neurons in the inferior vestibular nucleus in conditions of high-frequency stimulation of the paraventricular and supraoptic nuclei of the hypothalamus on exposure to vibration and systemic administration of proline-rich peptide 1. The poststimulus spike activity of neurons in the inferior vestibular nucleus in normal conditions was apparent mainly in the form of tetanic potentiation, while activity after vibration was apparent as post-tetanic potentiation. The combination of vibration and use of proline-rich peptide 1 restored the normal balance of excitatory and inhibitory poststimulus reactions and increased the level of excitability of neurons in the inferior vestibular nucleus.


inferior vestibular nucleus vibration single neuron activity high-frequency stimulation paraventricular and supraoptic nuclei of the hypothalamus proline-rich peptide 1 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • S. G. Sarkisyan
    • 1
  • V. A. Chavushyan
    • 2
  • V. S. Kamenetskii
    • 2
  • S. M. Minasyan
    • 1
  • K. V. Melkumyan
    • 1
  • J. S. Sarkisyan
    • 2
  1. 1.Erevan State UniversityErevanArmenia
  2. 2.Institute of PhysiologyNational Academy of Sciences of the Republic of ArmeniaErevanArmenia

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