Information Processing and Some Indicators of Brain Metabolism in Patients at Ultra-High Risk of Developing Endogenous Psychosis
Objective. Much attention in biological psychiatry in recent decades had been paid to functional and structural anomalies of the brain in groups at high risk of developing endogenous psychoses. Linkages between neurophysiological and neuroimaging parameters have been studied in cases of ultra-high risk of developing endogenous psychoses. The present report presents some results from the initial stage of this investigation. Materials and methods. A total of 56 patients aged 17–25 years with nonpsychotic mental disorders were studied. The control group consisted of 20 mentally healthy patients of comparable age and gender. Neurophysiological studies addressed measures characterizing the ability of the brain to “regulate” the volume of incoming information (sensory gating). Localizing proton MR spectroscopy was used simultaneously to determine some measures of metabolic processes in the brain (the glutamate/glutamine index and levels of N-acetylaspartate and choline-containing substances in the dorsolateral prefrontal cortex and thalamus of the left and right hemispheres and the genu and splenium of the corpus callosum. Results and conclusions. The results suggest impairment to the sensory filter in patients of the ultra-high risk group for developing endogenous psychoses; there was no correlation with the metabolic processes studied. These latter were normal or became normal during treatment.
Keywordsschizophrenia evoked potentials MR spectroscopy ultra-high risk group
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