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Neuroscience and Behavioral Physiology

, Volume 46, Issue 3, pp 284–290 | Cite as

Brain Microglia and Microglial Markers

  • D. E. Korzhevskii
  • O. V. Kirik
Article

Recent years have seen a continuing increase in interest in various aspects of the organization and functioning of microglia. However, data on contemporary immunocytochemical methods for detecting microglia are ambiguous and need to be made systematic. Attention in the present review is focused on microglial markers – proteins (Iba-1, CD11b, CD68, HLA-DR, and others) expressed by microgliocytes in normal conditions and on activation evoked by harmful factors. Characterization of markers and immunocytochemical microglial labeling methods is combined with analysis of reports on the origin and structural organization of microgliocytes.

Keywords

microglia brain immunocytochemistry Iba-1 CD11b CD68 OX-42 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Laboratory for the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology, Research Institute of Experimental Medicine, North-Western BranchRussian Academy of Medical SciencesSt. PetersburgRussia

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