Effects of Dynorphin A (1-13) on Lipid Peroxidation and the Activity of Antioxidant Enzymes in Immobilization Stress of Different Durations
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Experiments on rats showed that the selective opioid κ receptor agonist dynorphin A (1-13) had marked antioxidant actions in immobilization stress of different durations, apparent as reductions in lipid peroxidation products in liver tissues. The effects of this peptide on the activities of the antioxidant defense enzymes superoxide dismutase and catalase depended on the duration of stress. While the peptide had a notable stimulatory effect on catalase activity in animals subjected to immobilization for 3 h, this effect was significantly smaller in rats exposed to stress for 6 or 12 h. These studies demonstrated that dynorphin A (1-13) has a stimulatory action on superoxide dismutase activity in animals exposed to immobilization for 6 or 12 h, this being seen at all study time points. Peptide had no effect on the activity of this enzyme in rats exposed to immobilization stress for 3 h.
Keywordsstress lipid peroxidation antioxidant enzymes dynorphin
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