Neuroscience and Behavioral Physiology

, Volume 45, Issue 4, pp 393–397 | Cite as

Efficacy of Agomelatine in Depressive Disorders with Anxiety

  • A. A. Pribytkov
  • N. B. Panova
  • Yu. V. Popova
  • K. G. Emtsov

An open six-week study of the efficacy of agomelatine was performed in 35 patients with single depressive episodes or recurrent depression (ICD-10 diagnoses) and clinically severe anxiety. Agomelatine was found to be highly effective and safe in the treatment of mild and moderate depression combined with anxiety disorders. Decreases in the severity of the symptoms of depression and sleep disorders were seen from treatment week 1, with reductions in anxiety from treatment week 2. By the end of the study, therapeutic effects were seen in 71.9% of patients and the remission criteria were achieved in 68.8% of patients.


depression anxiety agomelatine sleep disorders 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • A. A. Pribytkov
    • 1
  • N. B. Panova
    • 2
  • Yu. V. Popova
    • 2
  • K. G. Emtsov
    • 3
  1. 1.Penza Institute of Advanced MedicalRussian Ministry of HealthPenzaRussia
  2. 2.Evgrafov Regional Psychiatric HospitalPenzaRussia
  3. 3.Togliatti Psychoneurological DispensaryTogliattiRussia

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